Aim: This umbrella review aimed to summarize the literature on the efficacy and safety of chronic diuretic treatment in adults. Findings: Certain diuretics or diuretic subclasses offer significant benefits for key clinical outcomes, such as reducing cardiovascular mortality and heart failure-related hospitalizations. However, chronic diuretic use carries potential risks, including an increased risk of hyperkalemia, with age-related differences in adverse event risks [older adults (≥ 65 years) facing higher risks, while younger populations do not show similar concerns]. Message: Further research is needed to establish diuretic efficacy and safety in populations commonly seen in clinical practice, especially older adults living with multimorbidity and frailty.
Effectiveness and safety of chronic diuretic use in older adults: an umbrella review of recently published systematic reviews and meta-analyses of randomized-controlled trials / Van Poelgeest, Eveline; Prokopidis, Konstantinos; Erdogan, Tuğba; Kwak, Min Ji; Piotrowicz, Karolina; Paoletti, Luca; Eidam, Annette; Koçak, Fatma Özge Kayhan; Ilhan, Birkan; Beccacece, Alessia; Soulis, George; Özkök, Serdar; Bahat, Gulistan; Topinková, Eva; Daams, Joost; Handoko, M. Louis; Goyal, Parag; Gąsowski, Jerzy; Cherubini, Antonio; Veronese, Nicola; Testa, Giuseppe Dario; Thompson, Wade; Van Der Velde, Nathalie; Null, Null. - In: EUROPEAN GERIATRIC MEDICINE. - ISSN 1878-7657. - 16:4(2025), pp. 1353-1387. [10.1007/s41999-025-01229-5]
Effectiveness and safety of chronic diuretic use in older adults: an umbrella review of recently published systematic reviews and meta-analyses of randomized-controlled trials
Cherubini, Antonio;
2025-01-01
Abstract
Aim: This umbrella review aimed to summarize the literature on the efficacy and safety of chronic diuretic treatment in adults. Findings: Certain diuretics or diuretic subclasses offer significant benefits for key clinical outcomes, such as reducing cardiovascular mortality and heart failure-related hospitalizations. However, chronic diuretic use carries potential risks, including an increased risk of hyperkalemia, with age-related differences in adverse event risks [older adults (≥ 65 years) facing higher risks, while younger populations do not show similar concerns]. Message: Further research is needed to establish diuretic efficacy and safety in populations commonly seen in clinical practice, especially older adults living with multimorbidity and frailty.| File | Dimensione | Formato | |
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