It is known that metallothionein (MT) mRNA expression first increases with age, but then decreases again in the very elderly. Here we report that MT protein levels also decrease in very old age, and that this is independent of dietary zinc intake. Age-related changes of MT, as well as alterations of zinc homeostasis (intracellular labile zinc and NO-induced zinc release), occur both in human PBMCs ex vivo and also in CD4+ T cell clones progressing through their finite life span in vitro. These results suggest that phenomena observed in very old people can be at least partially attributed to diminished cell proliferation. © 2008 Mary Ann Liebert, Inc.
Metallothionein downregulation in very old age: A phenomenon associated with cellular senescence? / Malavolta, M.; Cipriano, C.; Costarelli, L.; Giacconi, R.; Tesei, S.; Muti, E.; Piacenza, F.; Pierpaoli, S.; Larbi, A.; Pawelec, G.; Dedoussis, G.; Herbein, G.; Monti, D.; Jajte, J.; Rink, L.; Mocchegiani, E.. - In: REJUVENATION RESEARCH. - ISSN 1549-1684. - 11:2(2008), pp. 455-459. [10.1089/rej.2008.0679]
Metallothionein downregulation in very old age: A phenomenon associated with cellular senescence?
Malavolta M.
Primo
Conceptualization
;
2008-01-01
Abstract
It is known that metallothionein (MT) mRNA expression first increases with age, but then decreases again in the very elderly. Here we report that MT protein levels also decrease in very old age, and that this is independent of dietary zinc intake. Age-related changes of MT, as well as alterations of zinc homeostasis (intracellular labile zinc and NO-induced zinc release), occur both in human PBMCs ex vivo and also in CD4+ T cell clones progressing through their finite life span in vitro. These results suggest that phenomena observed in very old people can be at least partially attributed to diminished cell proliferation. © 2008 Mary Ann Liebert, Inc.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
