The role of metallothioneins (MTs) in aging is not completely understood. Several studies have shown evidence that these proteins could represent a defense system against oxidative damage, but survival studies on mice overexpressing MTs are poor. Here we describe a survival study performed on old MT-1-overexpressing mice (MT-TG) and their respective controls (C57BL/6J) fed a standard or zinc (Zn)-supplemented diet. MT-TG mice had significantly increased survival compared with control. Zn supplementation affects the survival curves of MT-TG and C57BL/6J mice differently. This study poses the basis for intervention based on gene therapy with MTs to enhance the health span of laboratory mice. © 2012 Mary Ann Liebert, Inc.
Survival study of metallothionein-1 transgenic mice and respective controls (C57BL/6J): Influence of a zinc-enriched environment / Malavolta, M.; Basso, A.; Piacenza, F.; Giacconi, R.; Costarelli, L.; Pierpaoli, S.; Mocchegiani, E.. - In: REJUVENATION RESEARCH. - ISSN 1549-1684. - 15:2(2012), pp. 140-143. [10.1089/rej.2011.1261]
Survival study of metallothionein-1 transgenic mice and respective controls (C57BL/6J): Influence of a zinc-enriched environment
Malavolta M.
Primo
Conceptualization
;
2012-01-01
Abstract
The role of metallothioneins (MTs) in aging is not completely understood. Several studies have shown evidence that these proteins could represent a defense system against oxidative damage, but survival studies on mice overexpressing MTs are poor. Here we describe a survival study performed on old MT-1-overexpressing mice (MT-TG) and their respective controls (C57BL/6J) fed a standard or zinc (Zn)-supplemented diet. MT-TG mice had significantly increased survival compared with control. Zn supplementation affects the survival curves of MT-TG and C57BL/6J mice differently. This study poses the basis for intervention based on gene therapy with MTs to enhance the health span of laboratory mice. © 2012 Mary Ann Liebert, Inc.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
