Zinc deficiency represents a risk factor for carotid stenosis (CS) development. In mammals, members of the ZIP family regulate zinc uptake, and hZip2 is a human zinc importer upregulated by zinc depletion. The purpose of this study was to investigate the association of a novel Zip2 Gln/Arg/Leu codon 2 polymorphism with CS, analyzing 250 CS patients and 259 elderly controls. CS patients showed an increased GG genotype frequency (60% vs. 47.5%), and a reduced TT frequency (6% vs. 10%) (p < 0.05 by χ2 test). In conclusion, Zip2 Gln/Arg/Leu polymorphism plays a role in the susceptibility to carotid artery disease. © 2008 Mary Ann Liebert, Inc.
A novel Zip2 Gln/Arg/Leu codon 2 polymorphism is associated with carotid artery disease in aging / Giacconi, R.; Muti, E.; Malavolta, M.; Cardelli, M.; Pierpaoli, S.; Cipriano, C.; Costarelli, L.; Tesei, S.; Saba, V.; Mocchegiani, E.. - In: REJUVENATION RESEARCH. - ISSN 1549-1684. - 11:2(2008), pp. 297-300. [10.1089/rej.2008.0671]
A novel Zip2 Gln/Arg/Leu codon 2 polymorphism is associated with carotid artery disease in aging
Malavolta M.Writing – Review & Editing
;Saba V.;
2008-01-01
Abstract
Zinc deficiency represents a risk factor for carotid stenosis (CS) development. In mammals, members of the ZIP family regulate zinc uptake, and hZip2 is a human zinc importer upregulated by zinc depletion. The purpose of this study was to investigate the association of a novel Zip2 Gln/Arg/Leu codon 2 polymorphism with CS, analyzing 250 CS patients and 259 elderly controls. CS patients showed an increased GG genotype frequency (60% vs. 47.5%), and a reduced TT frequency (6% vs. 10%) (p < 0.05 by χ2 test). In conclusion, Zip2 Gln/Arg/Leu polymorphism plays a role in the susceptibility to carotid artery disease. © 2008 Mary Ann Liebert, Inc.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
