The aim of this study was to validate an A/T single nucleotide polymorphism (SNP) corresponding to a LINE2 sequence located ∼1.1. kb downstream of the IL-6 gene (SNP BIEC2-911738) and to determine if this variant is correlated with interleukin 6 (IL-6) modulation or with different plasma concentrations of Zn, Cu, Se and Fe. The frequency of the newly described variant T ranged from 0 to 23.1% among different breeds of horses. SBIEC2-911738 was not associated with changes in IL-6 plasma levels. Increased Cu:Zn ratios were observed in horses carrying the AT genotype independently of breed when stabled for 24. h after physical exercise. © 2011 Elsevier Ltd.
A genetic variant near the equine interleukin 6 gene associated with copper:zinc ratio / Beghelli, D.; Giacconi, R.; Mocchegiani, E.; Cipriano, C.; Malavolta, M.; Renieri, C.. - In: THE VETERINARY JOURNAL. - ISSN 1090-0233. - 190:2(2011), pp. 143-145. [10.1016/j.tvjl.2010.12.028]
A genetic variant near the equine interleukin 6 gene associated with copper:zinc ratio
Malavolta M.Writing – Review & Editing
;Renieri C.
2011-01-01
Abstract
The aim of this study was to validate an A/T single nucleotide polymorphism (SNP) corresponding to a LINE2 sequence located ∼1.1. kb downstream of the IL-6 gene (SNP BIEC2-911738) and to determine if this variant is correlated with interleukin 6 (IL-6) modulation or with different plasma concentrations of Zn, Cu, Se and Fe. The frequency of the newly described variant T ranged from 0 to 23.1% among different breeds of horses. SBIEC2-911738 was not associated with changes in IL-6 plasma levels. Increased Cu:Zn ratios were observed in horses carrying the AT genotype independently of breed when stabled for 24. h after physical exercise. © 2011 Elsevier Ltd.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
