A phenol-interference decoupling method for hydroxyl-sanshools detection based on a modified electrode with magnesium-aluminum layered double hydroxide

In this work, a glassy carbon electrode modified with magnesium-aluminum layered double hydroxide (MgAl-LDH) was proposed to enhance the precision of hydroxy-sanshools quantification by mitigating polyphenol interference commonly found in the Zanthoxylum bungeanum pericarp during voltammetric assays. It was demonstrated that the MgAl-LDH-modified glassy carbon electrode effectively avoided the impact of polyphenols on hydroxy-sanshools by recovering their differential pulse voltammetric responses. Furthermore, the optimized method successfully quantified total hydroxy-sanshools in the linear range of 0.20–100.21 mg/g with good sensitivity (limit of detection and limit of quantification were 0.055 mg/L and 0.18 mg/L, respectively), and with recovery ranged from 95.66 % to 108.20 %. The intra-day and interday relative standard deviations were in the range of 0.43–3.13 % and 1.48–4.56 %, respectively. Additionally, the practicality of the developed approach was validated by quantifying hydroxy-sanshools in commercial Zanthoxylum bungeanum pericarp-related products, with results closely matching those obtained by high-performance liquid chromatography. These data reveals that the developed MgAl-LDH offers a novel strategy for modifying electrodes with high selectivity for the rapid monitoring of pungent substances in Zanthoxylum bungeanum pericarp.