Objective To investigate the impact of ageing on survival outcomes in Bacillus Calmette–Guérin (BCG) treated non-muscle invasive bladder cancer (NMIBC) patients and its synergy with adequate BCG treatment. Method Patients with NMIBC who received BCG treatment from 2001 to 2020 were divided into group 1 (<=70 years) and group 2 (>70 years). Overall Survival (OS), Cancer-Specifc Survival (CSS), Recurrence-Free Survival (RFS), and Progression-Free Survival (PFS) were analyzed using the Kaplan–Meier method. Multivariable Cox regression analysis was used to adjust potential confounding factors and to estimate Hazard Ratio (HR) and 95% Confdence Interval (CI). Subgroup analysis was performed according to adequate versus inadequate BCG treatment. Results Overall, 2602 NMIBC patients were included: 1051 (40.4%) and 1551 (59.6%) in groups 1 and 2, respectively. At median follow-up of 11.0 years, group 1 (<=70 years) was associated with better OS, CSS, and RFS, but not PFS as compared to group 2 (>70 years). At subgroup analysis, patients in group 1 treated with adequate BCG showed better OS, CSS, RFS, and PFS as compared with inadequate BCG treatment in group 2, while patients in group 2 receiving adequate BCG treatment had 41% less progression than those treated with inadequate BCG from the same group. Conclusions Being younger (<=70 years) was associated with better OS, CSS, and RFS, but not PFS. Older patients (>70 years) who received adequate BCG treatment had similar PFS as those younger with adequate BCG treatment.

Young age and adequate BCG are key factors for optimal BCG treatment efficacy in non-muscle-invasive bladder cancer / Liu, Kang; Nicoletti, Rossella; Zhao, Hongda; Chen, Xuan; Wu, Hongwei; Leung, Chi-Ho; D'Andrea, David; Laukhtina, Ekaterina; Soria, Francesco; Gallioli, Andrea; Wroclawski, Marcelo Langer; Castellani, Daniele; Gauhar, Vineet; Rivas, Juan Gomez; Enikeev, Dmitry; Gontero, Paolo; Shariat, Shahrokh F.; Chiu, Peter Ka-Fung; Ng, Chi-Fai; Teoh, Jeremy Yuen-Chun. - In: WORLD JOURNAL OF UROLOGY. - ISSN 1433-8726. - 42:(2024). [10.1007/s00345-024-05218-4]

Young age and adequate BCG are key factors for optimal BCG treatment efficacy in non-muscle-invasive bladder cancer

Castellani, Daniele;
2024-01-01

Abstract

Objective To investigate the impact of ageing on survival outcomes in Bacillus Calmette–Guérin (BCG) treated non-muscle invasive bladder cancer (NMIBC) patients and its synergy with adequate BCG treatment. Method Patients with NMIBC who received BCG treatment from 2001 to 2020 were divided into group 1 (<=70 years) and group 2 (>70 years). Overall Survival (OS), Cancer-Specifc Survival (CSS), Recurrence-Free Survival (RFS), and Progression-Free Survival (PFS) were analyzed using the Kaplan–Meier method. Multivariable Cox regression analysis was used to adjust potential confounding factors and to estimate Hazard Ratio (HR) and 95% Confdence Interval (CI). Subgroup analysis was performed according to adequate versus inadequate BCG treatment. Results Overall, 2602 NMIBC patients were included: 1051 (40.4%) and 1551 (59.6%) in groups 1 and 2, respectively. At median follow-up of 11.0 years, group 1 (<=70 years) was associated with better OS, CSS, and RFS, but not PFS as compared to group 2 (>70 years). At subgroup analysis, patients in group 1 treated with adequate BCG showed better OS, CSS, RFS, and PFS as compared with inadequate BCG treatment in group 2, while patients in group 2 receiving adequate BCG treatment had 41% less progression than those treated with inadequate BCG from the same group. Conclusions Being younger (<=70 years) was associated with better OS, CSS, and RFS, but not PFS. Older patients (>70 years) who received adequate BCG treatment had similar PFS as those younger with adequate BCG treatment.
2024
File in questo prodotto:
File Dimensione Formato  
Liu_Young-age-adequate-BCG-are-key-factors_2024.pdf

accesso aperto

Tipologia: Versione editoriale (versione pubblicata con il layout dell'editore)
Licenza d'uso: Creative commons
Dimensione 1.45 MB
Formato Adobe PDF
1.45 MB Adobe PDF Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11566/335133
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus ND
  • ???jsp.display-item.citation.isi??? ND
social impact