Histomorfometrical studies in rat cerebral cortex: normal ageing and cell loss.

Pugnaloni, Armanda; Pallotti, F.; Genova, M. G.; Zucchini, C.; Amati, S.; Tesei, M.; Biagini, G.; Lenaz, G.

One characteristic feature of the aged central nervous system (CNS) is neuron loss. Programmed cell death (PCD) has been implicated in neuronal death during development and may be involved in a number of age-related neurodegenerative diseases of the CNS. Cell death in the aging cerebral cortex was investigated in the present morphometric and immunohistochemical study of rat frontal cortex by detection of bcl-2 as the factor preventing PCD. The results were interpreted in the light of the bioenergetic features of aged motoneuron cells. Our results showed that 1) bcl-2 does not influence neuronal survival, and ii) the presence in aging frontal cortex of minor cellular morphometric and bioenergetic modifications, confirming the difference between normal aging and neurodegenerative disease.

Titolo:	Histomorfometrical studies in rat cerebral cortex: normal ageing and cell loss.
Autori:	PUGNALONI, Armanda Pallotti F. Genova M. G. Zucchini C. Amati S. Tesei M. Biagini G. Lenaz G. mostra contributor esterni nascondi contributor esterni
Data di pubblicazione:	1998
Rivista:	CELLULAR AND MOLECULAR BIOLOGY
Abstract:	One characteristic feature of the aged central nervous system (CNS) is neuron loss. Programmed cell death (PCD) has been implicated in neuronal death during development and may be involved in a number of age-related neurodegenerative diseases of the CNS. Cell death in the aging cerebral cortex was investigated in the present morphometric and immunohistochemical study of rat frontal cortex by detection of bcl-2 as the factor preventing PCD. The results were interpreted in the light of the bioenergetic features of aged motoneuron cells. Our results showed that 1) bcl-2 does not influence neuronal survival, and ii) the presence in aging frontal cortex of minor cellular morphometric and bioenergetic modifications, confirming the difference between normal aging and neurodegenerative disease.
Handle:	http://hdl.handle.net/11566/33474
Appare nelle tipologie:	1.1 Articolo in rivista

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