There is conflicting evidence that antioxidants contribute to maintaining cognitive function in elderly subjects. We investigated whether vitamin E plasma levels are related to the presence of dementia and cognitive impairment in a population-based cohort study conducted in Italy. A total of 1033 participants aged at least 65 years received clinical and neuropsychological examinations, donated blood for vitamin E analysis and had their diets assessed. Participants with plasma vitamin E levels in the bottom tertile had a significantly higher probability of being demented (OR 2.6, 95% CI 1.0–7.1) and also of suffering from cognitive impairment (OR 2.2, 95% CI 1.2–4.2) compared to those in the highest vitamin E tertile after adjustment for age, gender, education, lipid levels, energy intake, vitamin E intake, and smoking. This study supports the notion that higher vitamin E plasma levels might provide significant protection against cognitive impairment and dementia in elderly subjects.

Vitamin E levels, cognitive impairment and dementia in older persons: the InCHIANTI study / Cherubini, Antonio; Martin, A.; Andres Lacueva, C.; Di Iorio, A.; Lamponi, M.; Mecocci, Patrizia; Bartali, B.; Corsi, A.; Senin, Umberto; Ferrucci, L.. - In: NEUROBIOLOGY OF AGING. - ISSN 0197-4580. - STAMPA. - 26:7(2005), pp. 987-994.

Vitamin E levels, cognitive impairment and dementia in older persons: the InCHIANTI study

CHERUBINI, Antonio;
2005-01-01

Abstract

There is conflicting evidence that antioxidants contribute to maintaining cognitive function in elderly subjects. We investigated whether vitamin E plasma levels are related to the presence of dementia and cognitive impairment in a population-based cohort study conducted in Italy. A total of 1033 participants aged at least 65 years received clinical and neuropsychological examinations, donated blood for vitamin E analysis and had their diets assessed. Participants with plasma vitamin E levels in the bottom tertile had a significantly higher probability of being demented (OR 2.6, 95% CI 1.0–7.1) and also of suffering from cognitive impairment (OR 2.2, 95% CI 1.2–4.2) compared to those in the highest vitamin E tertile after adjustment for age, gender, education, lipid levels, energy intake, vitamin E intake, and smoking. This study supports the notion that higher vitamin E plasma levels might provide significant protection against cognitive impairment and dementia in elderly subjects.
2005
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11566/330519
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