Oxidative stress has been involved in the pahtogenesis of different neurodegenerative diseases. Recently high levels of 8-hydroxy-2’-deoxyguanosine [I)-OHdC), a sensitive marker of DNA damage, were found in both nuclear and mitochondrial DNA of the brain in Alzheimer disease (AD). In this study we measured 8-OHdG in lymphocyte DNA obtained from AD patients and from age- matched controls. The high levels of 8-OHdG found in the lymphocytes of AD patients support the hypothesis that a general imbalance is present in this disease between oxidants and antioxidants.
Oxidative stress and lymphocytes in Alzheimer disease / Mecocci, Patrizia; Cherubini, Antonio; Polidori, M. C.; Cecchetti, R; Chionne, F; Senin, U.. - In: ARCHIVES OF GERONTOLOGY AND GERIATRICS. - ISSN 0167-4943. - STAMPA. - 26:Suppl 1(1998), pp. 313-316. [10.1016/S0167-4943(98)80044-7]
Oxidative stress and lymphocytes in Alzheimer disease
CHERUBINI, Antonio;
1998-01-01
Abstract
Oxidative stress has been involved in the pahtogenesis of different neurodegenerative diseases. Recently high levels of 8-hydroxy-2’-deoxyguanosine [I)-OHdC), a sensitive marker of DNA damage, were found in both nuclear and mitochondrial DNA of the brain in Alzheimer disease (AD). In this study we measured 8-OHdG in lymphocyte DNA obtained from AD patients and from age- matched controls. The high levels of 8-OHdG found in the lymphocytes of AD patients support the hypothesis that a general imbalance is present in this disease between oxidants and antioxidants.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
