New acyl thiohydroxamates bearing an acridine moiety able to intercalate DNA double strand exhibit the capacity to cleave supercoiled DNA to linear DNA. EPR spin-trapping analysis has been employed to detect the formation of the carbon-centered radicals.
PHOTOCHEMICAL CLEAVAGE OF SUPERCOILED DNA BY N-ACYLOXYPYRIDINE-2-THIONE ACRIDINYL DERIVATIVES / E., Castagnino; S., Corsano; R., Barbaro; Carloni, Patricia. - In: JOURNAL OF CHEMICAL RESEARCH. SYNOPSES. - ISSN 0308-2342. - STAMPA. - 7:(1998), pp. 384-385. [10.1039/a708546j]
PHOTOCHEMICAL CLEAVAGE OF SUPERCOILED DNA BY N-ACYLOXYPYRIDINE-2-THIONE ACRIDINYL DERIVATIVES.
CARLONI, PATRICIA
1998-01-01
Abstract
New acyl thiohydroxamates bearing an acridine moiety able to intercalate DNA double strand exhibit the capacity to cleave supercoiled DNA to linear DNA. EPR spin-trapping analysis has been employed to detect the formation of the carbon-centered radicals.File in questo prodotto:
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