New acyl thiohydroxamates bearing an acridine moiety able to intercalate DNA double strand exhibit the capacity to cleave supercoiled DNA to linear DNA. EPR spin-trapping analysis has been employed to detect the formation of the carbon-centered radicals.
PHOTOCHEMICAL CLEAVAGE OF SUPERCOILED DNA BY N-ACYLOXYPYRIDINE-2-THIONE ACRIDINYL DERIVATIVES.
CARLONI, PATRICIA
1998-01-01
Abstract
New acyl thiohydroxamates bearing an acridine moiety able to intercalate DNA double strand exhibit the capacity to cleave supercoiled DNA to linear DNA. EPR spin-trapping analysis has been employed to detect the formation of the carbon-centered radicals.File in questo prodotto:
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