Objective: The outcome of patients with COVID-19 improved over the pandemic, including patients with systemic rheumatic diseases. However, data on patients with systemic sclerosis (SSc) are lacking. This study aimed to assess the outcome of patients with both SSc and COVID-19 over several waves. Methods: Patients with both SSc and COVID-19 who were registered in the European Scleroderma Trials and Research group (EUSTAR) were collected between April 2020 and April 2021. Patients were assigned to waves 1, 2, or 3 depending on the date of their COVID-19 diagnosis. Primary endpoints were death, intensive care unit stay, or ventilatory support (severe outcome). Subgroup analyses of patients who were hospitalized or died were conducted. General and SSc-specific characteristics and treatment were compared over the waves. Descriptive statistics and multivariate logistic regression were applied. Results: A total of 333 patients were included; 57 patients (17%) had a severe outcome, and 30 patients (9%) died. Compared to wave 1, significantly fewer patients with SSc suffered from severe COVID-19 in waves 2 and 3 (28.2% vs 9.8% and 12.7%; P < 0.001), fewer patients required hospitalization (46.7% vs 19.6% and 25.5%; P < 0.001) or ventilatory support (24.0% vs 8.7% and 10.9%; P = 0.001), and fewer patients died (15.7% vs 5.0% and 7.5%; P = 0.011). Patients were significantly younger, more often men, had less frequent arterial hypertension, and less SSc cardiac involvement over waves 1 to 3. Patients received significantly less medium to high doses of corticosteroids as they did SSc treatment. Conclusion: The outcome of patients with both SSc and COVID-19 improved significantly over time because of intrinsic and extrinsic factors.

Does the Impact of COVID-19 on Patients With Systemic Sclerosis Change Over Time? / Deibel, Elisabeth; Carreira, Patricia E; Vonk, Madelon; Del Papa, Nicoletta; Bečvář, Radim; Guillén-Del-Castillo, Alfredo; Campochiaro, Corrado; Poormoghim, Hadi; Liem, Sophie; Lazzaroni, Maria-Grazia; Giollo, Alessandro; Mekinian, Arsène; de Vries-Bouwstra, Jeska; De Santis, Maria; Balbir-Gurman, Alexandra; Mihai, Carina; De Luca, Giacomo; Moiseev, Sergey; Zanatta, Elisabetta; Foti, Rosario; Rednic, Simona; Denton, Christopher; Cutolo, Maurizio; Belloli, Laura; Airo, Paolo; Garzanova, Liudmila; Moroncini, Gianluca; İnanç, Murat; Panopoulos, Stylianos; Tandaipan, Jose-Luis; Chatelus, Emmanuel; Rosato, Edoardo; Kuwana, Masataka; Yavuz, Sule; Alegre-Sancho, Juan J; Smith, Vanessa; Szűcs, Gabriella; Henes, Joerg; Rodríguez-Pintó, Ignasi; Atzeni, Fabiola; Spierings, Julia; Truchetet, Marie-Elise; Milchert, Marcin; Brito de Araujo, Daniel; Riemekasten, Gabriela; Bernardino, Vera; Martin, Thierry; Del Galdo, Francesco; Vacca, Alessandra; Mendoza, Fabian; Midtvedt, Øyvind; Murdaca, Giuseppe; Santiago, Tânia; Codullo, Veronica; Cacciapaglia, Fabio; Walker, Ulrich; Brunborg, Cathrine; Tirelli, Francesca; Allanore, Yannick; Furst, Daniel E; Matucci, Marco; Gabrielli, Armando; Distler, Oliver; Hoffmann-Vold, Anna-Maria. - In: ARTHRITIS CARE & RESEARCH. - ISSN 2151-4658. - 76:1(2024), pp. 88-97. [10.1002/acr.25226]

Does the Impact of COVID-19 on Patients With Systemic Sclerosis Change Over Time?

Moroncini, Gianluca;Gabrielli, Armando;
2024-01-01

Abstract

Objective: The outcome of patients with COVID-19 improved over the pandemic, including patients with systemic rheumatic diseases. However, data on patients with systemic sclerosis (SSc) are lacking. This study aimed to assess the outcome of patients with both SSc and COVID-19 over several waves. Methods: Patients with both SSc and COVID-19 who were registered in the European Scleroderma Trials and Research group (EUSTAR) were collected between April 2020 and April 2021. Patients were assigned to waves 1, 2, or 3 depending on the date of their COVID-19 diagnosis. Primary endpoints were death, intensive care unit stay, or ventilatory support (severe outcome). Subgroup analyses of patients who were hospitalized or died were conducted. General and SSc-specific characteristics and treatment were compared over the waves. Descriptive statistics and multivariate logistic regression were applied. Results: A total of 333 patients were included; 57 patients (17%) had a severe outcome, and 30 patients (9%) died. Compared to wave 1, significantly fewer patients with SSc suffered from severe COVID-19 in waves 2 and 3 (28.2% vs 9.8% and 12.7%; P < 0.001), fewer patients required hospitalization (46.7% vs 19.6% and 25.5%; P < 0.001) or ventilatory support (24.0% vs 8.7% and 10.9%; P = 0.001), and fewer patients died (15.7% vs 5.0% and 7.5%; P = 0.011). Patients were significantly younger, more often men, had less frequent arterial hypertension, and less SSc cardiac involvement over waves 1 to 3. Patients received significantly less medium to high doses of corticosteroids as they did SSc treatment. Conclusion: The outcome of patients with both SSc and COVID-19 improved significantly over time because of intrinsic and extrinsic factors.
2024
File in questo prodotto:
File Dimensione Formato  
Arthritis Care Research - 2023 - Deibel - Does the Impact of COVID‐19 on Patients With Systemic Sclerosis Change Over.pdf

accesso aperto

Tipologia: Versione editoriale (versione pubblicata con il layout dell'editore)
Licenza d'uso: Creative commons
Dimensione 831.17 kB
Formato Adobe PDF
831.17 kB Adobe PDF Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11566/328656
Citazioni
  • ???jsp.display-item.citation.pmc??? 0
  • Scopus 1
  • ???jsp.display-item.citation.isi??? 1
social impact