We report the first successful treatment with the thrombopoietin receptor mimetic eltrombopag in a patient with severe aplastic anaemia (SAA) associated with HIV infection, thereby avoiding the use of standard immunosuppressive agents for treatment of SAA. Eltrombopag induced a trilineage haematological response. We also show that eltrombopag had an immunomodulatory role with a decrease in proinflammatory T helpers (Th1 and Th17 cells) with increased T-regulatory cell/Thelper ratio, thus contributing to recovery of haemopoiesis.
Successful treatment of aplastic anaemia associated with HIV infection with eltrombopag: Implications for a possible immunomodulatory role / Bart-Smith, E. E.; Kordasti, S.; Kulasekararaj, A. G.; Richardson, D.; Mufti, G. J.; Marsh, J. C. W.. - In: AIDS. - ISSN 0269-9370. - 28:18(2014), pp. 2786-2788. [10.1097/QAD.0000000000000504]
Successful treatment of aplastic anaemia associated with HIV infection with eltrombopag: Implications for a possible immunomodulatory role
Kordasti S.Writing – Original Draft Preparation
;
2014-01-01
Abstract
We report the first successful treatment with the thrombopoietin receptor mimetic eltrombopag in a patient with severe aplastic anaemia (SAA) associated with HIV infection, thereby avoiding the use of standard immunosuppressive agents for treatment of SAA. Eltrombopag induced a trilineage haematological response. We also show that eltrombopag had an immunomodulatory role with a decrease in proinflammatory T helpers (Th1 and Th17 cells) with increased T-regulatory cell/Thelper ratio, thus contributing to recovery of haemopoiesis.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
