Foxp3+ regulatory T cells (Tregs) play a central role in maintaining immune tolerance. A reduction in the function of Tregs is a key feature of autoimmune diseases, whereas their expansion in malignant diseases leads to the suppression of host antitumor responses. We analyzed the absolute number of CD4(+) and CD8(+) Tregs in the peripheral blood of 52 patients with myelodysplastic syndrome (IMDS) and show a significant correlation between increased number of CD4(+) Tregs and MDS subgroups with 5% or more bone marrow blasts (P<.001), high International Prognostic Scoring System (IPSS) score (P <.001), and disease progression (P <.001), whereas no correlation between CD8(+) Tregs and prognostic variables was observed. The CD4(+) Tregs showed a polyclonal spectratype, and the percentage of the naive subset was significantly higher in the high-risk patients compared with low-risk or healthy agematched donors (P =.032). Our data suggest that CD4(+) Treg expansion is a feature of high-risk MDS and progression to aggressive subtypes of the disease.
CD4+CD25high Foxp3+ regulatory T cells in myelodysplastic syndrome (MDS) / Kordasti, Shahram Y; Ingram, Wendy; Hayden, Janet; Darling, David; Barber, Linda; Afzali, Behdad; Lombardi, Giovanna; Wlodarski, Marcin W; Maciejewski, Jaroslaw P; Farzaneh, Farzin; Mufti, Ghulam J. - In: BLOOD. - ISSN 0006-4971. - 110:3(2007). [10.1182/blood-2007-01-067546]
CD4+CD25high Foxp3+ regulatory T cells in myelodysplastic syndrome (MDS)
Kordasti, Shahram YPrimo
Formal Analysis
;
2007-01-01
Abstract
Foxp3+ regulatory T cells (Tregs) play a central role in maintaining immune tolerance. A reduction in the function of Tregs is a key feature of autoimmune diseases, whereas their expansion in malignant diseases leads to the suppression of host antitumor responses. We analyzed the absolute number of CD4(+) and CD8(+) Tregs in the peripheral blood of 52 patients with myelodysplastic syndrome (IMDS) and show a significant correlation between increased number of CD4(+) Tregs and MDS subgroups with 5% or more bone marrow blasts (P<.001), high International Prognostic Scoring System (IPSS) score (P <.001), and disease progression (P <.001), whereas no correlation between CD8(+) Tregs and prognostic variables was observed. The CD4(+) Tregs showed a polyclonal spectratype, and the percentage of the naive subset was significantly higher in the high-risk patients compared with low-risk or healthy agematched donors (P =.032). Our data suggest that CD4(+) Treg expansion is a feature of high-risk MDS and progression to aggressive subtypes of the disease.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
