Hidradenitis suppurativa (HS) is a chronic, recurrent, and inflammatory skin disease characterized by painful, deep-seated, nodules, abscesses, and sinus tracts in sensitive areas of the body, including axillary, inguinal, and anogenital regions. Antibiotics represent the first-line pharmacological treatment of HS because of their anti-inflammatory properties and antimicrobial effects. This narrative review summarizes the most significant current issues on the role of systemic antibiotics in the management of HS, critically analyzing the main limits of their use (antibiotic resistance and toxicity). Although, in the last decades, several cytokines have been implicated in the pathomechanism of HS and the research on the use of novel biologic agents in HS has been intensified, antibiotics remain a valid therapeutic approach. Future challenges regarding antibiotic therapy in HS comprise their use in association with biologics in the management of acute flare or as a bridge therapy to surgery.

Systemic antibiotic therapy in hidradenitis suppurativa: a review on treatment landscape and current issues / Molinelli, Elisa; De Simoni, Edoardo; Candelora, Matteo; Sapigni, Claudia; Brisigotti, Valerio; Rizzetto, Giulio; Offidani, Annamaria; Simonetti, Oriana. - In: ANTIBIOTICS. - ISSN 2079-6382. - 12:6(2023). [10.3390/antibiotics12060978]

Systemic antibiotic therapy in hidradenitis suppurativa: a review on treatment landscape and current issues

Molinelli, Elisa
Co-primo
;
De Simoni, Edoardo
Co-primo
;
Candelora, Matteo
Co-primo
;
Sapigni, Claudia;Brisigotti, Valerio;Rizzetto, Giulio;Offidani, Annamaria;Simonetti, Oriana
Ultimo
2023-01-01

Abstract

Hidradenitis suppurativa (HS) is a chronic, recurrent, and inflammatory skin disease characterized by painful, deep-seated, nodules, abscesses, and sinus tracts in sensitive areas of the body, including axillary, inguinal, and anogenital regions. Antibiotics represent the first-line pharmacological treatment of HS because of their anti-inflammatory properties and antimicrobial effects. This narrative review summarizes the most significant current issues on the role of systemic antibiotics in the management of HS, critically analyzing the main limits of their use (antibiotic resistance and toxicity). Although, in the last decades, several cytokines have been implicated in the pathomechanism of HS and the research on the use of novel biologic agents in HS has been intensified, antibiotics remain a valid therapeutic approach. Future challenges regarding antibiotic therapy in HS comprise their use in association with biologics in the management of acute flare or as a bridge therapy to surgery.
2023
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11566/328472
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