COVID-19 breakthrough infections in type 1 diabetes mellitus: a cross-sectional study by the COVID-19 Vaccination in Autoimmune Diseases (COVAD) Group

Panchawagh, Suhrud; Ravichandran, Naveen; Barman, Bhupen; Nune, Arvind; Javaid, Mahnoor; Abraham Edgar Gracia-Ramos,; Day, Jessica; Joshi, Mrudula; Kuwana, Masataka; Saha, Sreoshy; Arunkumar, R Pande; Carlo Vinicio Caballero-Uribe,; Velikova, Tsvetelina; Parodis, Ioannis; Knitza, Johannes; Kadam, Esha; Ai Lyn Tan,; Samuel Katsuyuki Shinjo,; Hiya Boro Parikshit Sen,; Nikiphorou, Elena; Ziade, Nelly; Milchert, Marcin; Cavagna, Lorenzo; Yi Ming Chen,; Makol, Ashima; Agarwal, Vishwesh; Patel, Aarat; John, D Pauling; Wincup, Chris; Erick Adrian Zamora Tehozol,; Jorge Rojas Serrano,; Ignacia García-De La Torre,; Iris, J Colunga-Pedraza; Merayo-Chalico, Javier; Okwara Celestine Chibuzo,; Katchamart, Wanruchada; Phonpen Akawatcharangura Goo,; Shumnalieva, Russka; Leonardo Santos Hoff,; Lina El Kibbi,; Halabi, Hussein; Vaidya, Binit; Syahrul Sazliyana Shaharir,; Hasan, Atmtanveer; Dey, Dzifa; Carlos Enrique Toro Gutiérrez,; James, B Lilleker; Salim, Babur; Gheita, Tamer; Distler, Oliver; Miguel, A Saavedra; Kardes, Sinan; Andreoli, Laura; Lini, Daniele; Schreiber, Karen; Melinda Nagy Vince,; Yogesh Preet Singh,; Ranjan, Rajiv; Jain, Avinash; Sapan, C Pandya; Rakesh Kumar Pilania,; Sharma, Aman; Manesh Manoj, M; Gupta, Vikas; Chengappa, G Kavadichanda; Pradeepta Sekhar Patro,; Ajmani, Sajal; Phatak, Sanat; Rudra Prosad Goswami,; Abhra Chandra Chowdhury,; Ashish Jacob Mathew,; Shenoy, Padnamabha; Asranna, Ajay; Keerthi Talari Bommakanti,; Shukla, Anuj; Arunkumar, R Pande; Chandwar, Kunal; Ghodke, Akanksha; Zoha Zahid Fazal,; Döndü Üsküdar Cansu,; Yıldırım, Reşit; Armen Yuri Gasparyan,; Nicoletta Del Papa,; Sambataro, Gianluca; Fabiola, Atzeni; Govoni, Marcello; Parisi, Simone; Elena Bartoloni Bocci,; Gian Domenico Sebastiani,; Fusaro, Enrico; Sebastiani, Marco; Quartuccio, Luca; Franceschini, Franco; Pier Paolo Sainaghi,; Orsolini, Giovanni; DE ANGELIS, Rossella; Maria Giovanna Danielli,; Venerito, Vincenzo; Grignaschi, Silvia; Giollo, Alessandro; Alluno, Alessia; Ioannone, Florenzo; Fornaro, Marco; Lisa, S Traboco; Suryo Anggoro Kusumo Wibowo,; Loarce-Martos, Jesús; Prieto-González, Sergio; Raquel Aranega Gonzalez,; Yoshida, Akira; Nakashima, Ran; Sato, Shinji; Kimura, Naoki; Kaneko, Yuko; Gono, Takahisa; Tomaras, Stylianos; Fabian Nikolai Proft,; Holzer, Marie-Therese; Margarita Aleksandrovna Gromova,; Aharonov, Or; Griger, Zoltán; Hmamouchi, Ihsane; Imane El Bouchti,; Baba, Zineb; Giannini, Margherita; Maurier, François; Campagne, Julien; Meyer, Alain; Langguth, Daman; Limaye, Vidya; Needham, Merrilee; Srivastav, Nilesh; Hudson, Marie; Landon-Cardinal, Océane; Wilmer Gerardo Rojas Zuleta,; Arbeláez, Álvaro; Cajas, Javier; José António Pereira Silva,; João Eurico Fonseca,; Zimba, Olena; Bohdana, Doskaliuk; Ima-Edomwonyi, Uyi; Dedeke, Ibukunoluwa; Airenakho, Emorinken; Nwankwo Henry Madu,; Yerima, Abubakar; Olaosebikan, Hakeem; Becky, A; Oruma Devi Koussougbo,; Palalane, Elisa; So, Ho; Manuel Francisco Ugarte-Gil,; Chinchay, Lyn; José Proaño Bernaola,; Pimentel, Victorio; Hanan Mohammed Fathi,; Reem Hamdy, A Mohammed; Harifi, Ghita; Fuentes-Silva, Yurilís; Cabriza, Karoll; Losanto, Jonathan; Colaman, Nelly; Cachafeiro-Vilar, Antonio; Generoso Guerra Bautista,; Enrique Julio Giraldo Ho,; González, Raúl; Lilith Stange Nunez,; Cristian Vergara, M; Jossiell Then Báez,; Alonzo, Hugo; Carlos Benito Santiago Pastelin,; Rodrigo García Salinas,; Alejandro Quiñónez Obiols,; Chávez, Nilmo; Andrea Bran Ordóñez,; Alberto Reyes Llerena,; Sierra-Zorita, Radames; Arrieta, Dina; Eduardo Romero Hidalgo,; Saenz, Ricardo; Idania Escalante, M; Calapaqui, Wendy; Quezada, Ivonne; Arredondo, Gabriela; Aggarwal, Rohit; Agarwal, Vikas; Chatterjee, Tulika; Gupta, Latika

doi:10.1007/s00296-023-05496-y

To investigate the frequency, profile, and severity of COVID-19 breakthrough infections (BI) in patients with type I diabetes mellitus (T1DM) compared to healthy controls (HC) after vaccination. The second COVID-19 Vaccination in Autoimmune Diseases (COVAD-2) survey is a multinational cross-sectional electronic survey which has collected data on patients suffering from various autoimmune diseases including T1DM. We performed a subgroup analysis on this cohort to investigate COVID-19 BI characteristics in patients with T1DM. Logistic regression with propensity score matching analysis was performed. A total of 9595 individuals were included in the analysis, with 100 patients having T1DM. Among the fully vaccinated cohort, 16 (16%) T1DM patients had one BI and 2 (2%) had two BIs. No morbidities or deaths were reported, except for one patient who required hospitalization with oxygen without admission to intensive care. The frequency, clinical features, and severity of BIs were not significantly different between T1DM patients and HCs after adjustment for confounding factors. Our study did not show any statistically significant differences in the frequency, symptoms, duration, or critical care requirements between T1DM and HCs after COVID-19 vaccination. Further research is needed to identify factors associated with inadequate vaccine response in patients with BIs, especially in patients with autoimmune diseases.

COVID-19 breakthrough infections in type 1 diabetes mellitus: a cross-sectional study by the COVID-19 Vaccination in Autoimmune Diseases (COVAD) Group / Panchawagh, Suhrud; Ravichandran, Naveen; Barman, Bhupen; Nune, Arvind; Javaid, Mahnoor; Edgar Gracia-Ramos, Abraham; Day, Jessica; Joshi, Mrudula; Kuwana, Masataka; Saha, Sreoshy; R Pande, Arunkumar; Vinicio Caballero-Uribe, Carlo; Velikova, Tsvetelina; Parodis, Ioannis; Knitza, Johannes; Kadam, Esha; Lyn Tan, Ai; Katsuyuki Shinjo, Samuel; Boro Parikshit Sen, Hiya; Nikiphorou, Elena; Ziade, Nelly; Milchert, Marcin; Cavagna, Lorenzo; Ming Chen, Yi; Makol, Ashima; Agarwal, Vishwesh; Patel, Aarat; D Pauling, John; Wincup, Chris; Adrian Zamora Tehozol, Erick; Rojas Serrano, Jorge; García-De La Torre, Ignacia; J Colunga-Pedraza, Iris; Merayo-Chalico, Javier; Celestine Chibuzo, Okwara; Katchamart, Wanruchada; Akawatcharangura Goo, Phonpen; Shumnalieva, Russka; Santos Hoff, Leonardo; El Kibbi, Lina; Halabi, Hussein; Vaidya, Binit; Sazliyana Shaharir, Syahrul; Hasan, Atmtanveer; Dey, Dzifa; Enrique Toro Gutiérrez, Carlos; B Lilleker, James; Salim, Babur; Gheita, Tamer; Distler, Oliver; A Saavedra, Miguel; Kardes, Sinan; Andreoli, Laura; Lini, Daniele; Schreiber, Karen; Nagy Vince, Melinda; Preet Singh, Yogesh; Ranjan, Rajiv; Jain, Avinash; C Pandya, Sapan; Kumar Pilania, Rakesh; Sharma, Aman; M, Manesh Manoj; Gupta, Vikas; G Kavadichanda, Chengappa; Sekhar Patro, Pradeepta; Ajmani, Sajal; Phatak, Sanat; Prosad Goswami, Rudra; Chandra Chowdhury, Abhra; Jacob Mathew, Ashish; Shenoy, Padnamabha; Asranna, Ajay; Talari Bommakanti, Keerthi; Shukla, Anuj; R Pande, Arunkumar; Chandwar, Kunal; Ghodke, Akanksha; Zahid Fazal, Zoha; Üsküdar Cansu, Döndü; Yıldırım, Reşit; Yuri Gasparyan, Armen; Del Papa, Nicoletta; Sambataro, Gianluca; Fabiola, Atzeni; Govoni, Marcello; Parisi, Simone; Bartoloni Bocci, Elena; Domenico Sebastiani, Gian; Fusaro, Enrico; Sebastiani, Marco; Quartuccio, Luca; Franceschini, Franco; Paolo Sainaghi, Pier; Orsolini, Giovanni; DE ANGELIS, Rossella; Giovanna Danielli, Maria; Venerito, Vincenzo; Grignaschi, Silvia; Giollo, Alessandro; Alluno, Alessia; Ioannone, Florenzo; Fornaro, Marco; S Traboco, Lisa; Anggoro Kusumo Wibowo, Suryo; Loarce-Martos, Jesús; Prieto-González, Sergio; Aranega Gonzalez, Raquel; Yoshida, Akira; Nakashima, Ran; Sato, Shinji; Kimura, Naoki; Kaneko, Yuko; Gono, Takahisa; Tomaras, Stylianos; Nikolai Proft, Fabian; Holzer, Marie-Therese; Aleksandrovna Gromova, Margarita; Aharonov, Or; Griger, Zoltán; Hmamouchi, Ihsane; El Bouchti, Imane; Baba, Zineb; Giannini, Margherita; Maurier, François; Campagne, Julien; Meyer, Alain; Langguth, Daman; Limaye, Vidya; Needham, Merrilee; Srivastav, Nilesh; Hudson, Marie; Landon-Cardinal, Océane; Gerardo Rojas Zuleta, Wilmer; Arbeláez, Álvaro; Cajas, Javier; António Pereira Silva, José; Eurico Fonseca, João; Zimba, Olena; Bohdana, Doskaliuk; Ima-Edomwonyi, Uyi; Dedeke, Ibukunoluwa; Airenakho, Emorinken; Henry Madu, Nwankwo; Yerima, Abubakar; Olaosebikan, Hakeem; A, Becky; Devi Koussougbo, Oruma; Palalane, Elisa; So, Ho; Francisco Ugarte-Gil, Manuel; Chinchay, Lyn; Proaño Bernaola, José; Pimentel, Victorio; Mohammed Fathi, Hanan; A Mohammed, Reem Hamdy; Harifi, Ghita; Fuentes-Silva, Yurilís; Cabriza, Karoll; Losanto, Jonathan; Colaman, Nelly; Cachafeiro-Vilar, Antonio; Guerra Bautista, Generoso; Julio Giraldo Ho, Enrique; González, Raúl; Stange Nunez, Lilith; M, Cristian Vergara; Then Báez, Jossiell; Alonzo, Hugo; Benito Santiago Pastelin, Carlos; García Salinas, Rodrigo; Quiñónez Obiols, Alejandro; Chávez, Nilmo; Bran Ordóñez, Andrea; Reyes Llerena, Alberto; Sierra-Zorita, Radames; Arrieta, Dina; Romero Hidalgo, Eduardo; Saenz, Ricardo; M, Idania Escalante; Calapaqui, Wendy; Quezada, Ivonne; Arredondo, Gabriela; Aggarwal, Rohit; Agarwal, Vikas; Chatterjee, Tulika; Gupta, Latika. - In: RHEUMATOLOGY INTERNATIONAL. - ISSN 1437-160X. - 44:(2024), pp. 73-80. [10.1007/s00296-023-05496-y]