Brodalumab is a recombinant, fully human immunoglobulin IgG2 monoclonal antibody specifically targeted against interleukin-17RA that has been approved for the treatment of moderate-to-severe psoriasis in Europe. We developed a Delphi consensus document focused on brodalumab for the treatment of moderate-to-severe psoriasis. Based on published literature and their clinical experience a steering committee drafted 17 statements covering 7 domains specific to the treatment of moderate-to-severe psoriasis with brodalumab. A panel of 32 Italian dermatologists indicated their level of agreement using a 5-point Likert scale (from 1 = "strongly disagree" to 5 = "strongly agree") using an online modified Delphi method. After the first round of voting (32 participants), positive consensus was reached for 15/17 (88.2%) of the proposed statements. Following a face-to-face virtual meeting, the steering committee decided that 5 statements would form "main principles" and 10 statements formed the final list. After a second round of voting, consensus was reached in 4/5 (80%) of the main principles and 8/10 (80%) for consensus statements. The final list of 5 main principles and 10 consensus statements identify key indications specific to the use of brodalumab in the treatment of moderate-to-severe psoriasis in Italy. These statements aid dermatologists in the management of patients with moderate-to-severe psoriasis.
Brodalumab for the Treatment of Moderate-to-Severe Psoriasis: An Expert Delphi Consensus Statement / Fargnoli, Maria Concetta; Bardazzi, Federico; Bianchi, Luca; Dapavo, Paolo; Fabbrocini, Gabriella; Gisondi, Paolo; Micali, Giuseppe; Offidani, Anna Maria; Pellacani, Giovanni; Skroza, Nevena; Angileri, Rosa Giuseppa; Burlando, Martina; Campanati, Anna; Carrera, Carlo Giovanni; Chiricozzi, Andrea; Conti, Andrea; Simone, Clara De; Di Lernia, Vito; Errichetti, Enzo; Galluzzo, Marco; Guarneri, Claudio; Lasagni, Claudia; Lembo, Serena; Loconsole, Francesco; Megna, Matteo; Musumeci, Maria Letizia; Prignano, Francesca; Richetta, Antonio Giovanni; Trovato, Emanuele; Venturini, Marina; Peris, Ketty; Pinton, Piergiacomo Calzavara. - In: JOURNAL OF CLINICAL MEDICINE. - ISSN 2077-0383. - 12:10(2023), p. 3545. [10.3390/jcm12103545]