N-Formyl-methionyl-leucyl-phenylalanine (F-MLP)-induced chemotaxis and luminolamplified chemiluminescence were studied in isolated human polymorphonuclear leucocytes (PMN) and exposed to acrylonitrile (ACN) in vitro. Chemotaxis was reduced at ACN concentrations of 3 mm and above, while respiratory burst was affected at ACN concentrations of 18mm and above. The ACN concentrations were highly correlated both with decreased chemotactic activity (r = 0.75; P < 0.05) and with decreased respiratory burst (r = 0.93; P < 0.01).

In vitro effect of acrylonitrile on specific activities of human polymorphonuclear leucocytes.

GOVERNA, Mario;VALENTINO, Matteo;AMATI, Monica
1995-01-01

Abstract

N-Formyl-methionyl-leucyl-phenylalanine (F-MLP)-induced chemotaxis and luminolamplified chemiluminescence were studied in isolated human polymorphonuclear leucocytes (PMN) and exposed to acrylonitrile (ACN) in vitro. Chemotaxis was reduced at ACN concentrations of 3 mm and above, while respiratory burst was affected at ACN concentrations of 18mm and above. The ACN concentrations were highly correlated both with decreased chemotactic activity (r = 0.75; P < 0.05) and with decreased respiratory burst (r = 0.93; P < 0.01).
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11566/31974
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