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EnglishN-Formyl-methionyl-leucyl-phenylalanine (F-MLP)-induced chemotaxis and luminolamplified chemiluminescence were studied in isolated human polymorphonuclear leucocytes (PMN) and exposed to acrylonitrile (ACN) in vitro. Chemotaxis was reduced at ACN concentrations of 3 mm and above, while respiratory burst was affected at ACN concentrations of 18mm and above. The ACN concentrations were highly correlated both with decreased chemotactic activity (r = 0.75; P < 0.05) and with decreased respiratory burst (r = 0.93; P < 0.01).
http://hdl.handle.net/11566/31974| Titolo: | In vitro effect of acrylonitrile on specific activities of human polymorphonuclear leucocytes. |
| Autori interni: | GOVERNA, Mario VALENTINO, Matteo AMATI, Monica |
| Data di pubblicazione: | 1995 |
| Rivista: | TOXICOLOGY IN VITRO |
| Abstract: | N-Formyl-methionyl-leucyl-phenylalanine (F-MLP)-induced chemotaxis and luminolamplified chemiluminescence were studied in isolated human polymorphonuclear leucocytes (PMN) and exposed to acrylonitrile (ACN) in vitro. Chemotaxis was reduced at ACN concentrations of 3 mm and above, while respiratory burst was affected at ACN concentrations of 18mm and above. The ACN concentrations were highly correlated both with decreased chemotactic activity (r = 0.75; P < 0.05) and with decreased respiratory burst (r = 0.93; P < 0.01). |
| Handle: | http://hdl.handle.net/11566/31974 |
| Appare nelle tipologie: | 1.1 Articolo in rivista |
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