Although coagulase negative staphylococci are rarely associated with complicated diseases, in some cases they cause life-threatening infections. Here we described a clinical case of a bacteremia due to a methicillin- and linezolid-resistant Staphylococcus capitis in a patient previously treated with linezolid. Whole genome sequencing revealed the common mutation G2576T in all rDNA 23S alleles and several acquired resistance genes. Moreover, the isolate was epidemiologically distant from the NRCS-A clade, usually responsible for nosocomial infections in neonatal intensive care units. Our findings further confirm the ability of minor staphylococci to acquire antibiotic resistances and challenge the treatment of these infections.

Genomic Analysis of a Linezolid-Resistant Staphylococcus capitis Causing Bacteremia: Report from a University Hospital in Central Italy / Brescini, Lucia; Fioriti, Simona; Coccitto, Sonia N; Cinthi, Marzia; Mingoia, Marina; Cirioni, Oscar; Giacometti, Andrea; Giovanetti, Eleonora; Morroni, Gianluca; Brenciani, Andrea. - In: MICROBIAL DRUG RESISTANCE. - ISSN 1076-6294. - (2023). [10.1089/mdr.2022.0330]

Genomic Analysis of a Linezolid-Resistant Staphylococcus capitis Causing Bacteremia: Report from a University Hospital in Central Italy

Brescini, Lucia
Primo
;
Fioriti, Simona
Secondo
;
Coccitto, Sonia N;Cinthi, Marzia;Mingoia, Marina;Cirioni, Oscar;Giacometti, Andrea;Giovanetti, Eleonora;Morroni, Gianluca
Penultimo
;
Brenciani, Andrea
Ultimo
Writing – Review & Editing
2023-01-01

Abstract

Although coagulase negative staphylococci are rarely associated with complicated diseases, in some cases they cause life-threatening infections. Here we described a clinical case of a bacteremia due to a methicillin- and linezolid-resistant Staphylococcus capitis in a patient previously treated with linezolid. Whole genome sequencing revealed the common mutation G2576T in all rDNA 23S alleles and several acquired resistance genes. Moreover, the isolate was epidemiologically distant from the NRCS-A clade, usually responsible for nosocomial infections in neonatal intensive care units. Our findings further confirm the ability of minor staphylococci to acquire antibiotic resistances and challenge the treatment of these infections.
2023
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11566/316655
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