Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease characterized by painful nodules, abscesses, and fistulas, localized to the areas of the folds where apocrine glands are present: the armpits, groin, inframammary region, and genital or perineal region. The management is still challenging, and it includes mainly systemic antibiotics, immunosuppressors, and biologic agents. Antibiotics are frequently used in the management of HS for their anti-inflammatory, immunomodulatory, and antimicrobial properties, but no data have been reported regarding the use of dalbavancin in HS. The aim of our practice was to evaluate efficacy, flare, and disease-free survival after dalbavancin therapy in a selected population with HS. We report the experience of the Ancona Dermatology Clinic in treating HS flare-ups with dalbavancin and its rationale for use. Our observation shows that the use of dalbavancin is an effective and well-tolerated treatment for the management of Hurley stage II-III HS; currently, dalbavancin should be considered as a supportive therapy for selected patients.

The Effect of Dalbavancin in Moderate to Severe Hidradenitis Suppurativa / Molinelli, Elisa; Sapigni, Claudia; D'Agostino, Giovanni Marco; Brisigotti, Valerio; Rizzetto, Giulio; Bobyr, Ivan; Cirioni, Oscar; Giacometti, Andrea; Brescini, Lucia; Mazzanti, Sara; Offidani, Annamaria; Simonetti, Oriana. - In: ANTIBIOTICS. - ISSN 2079-6382. - ELETTRONICO. - 11:11(2022), pp. 1573-1579. [10.3390/antibiotics11111573]

The Effect of Dalbavancin in Moderate to Severe Hidradenitis Suppurativa

Molinelli, Elisa;Sapigni, Claudia;D'Agostino, Giovanni Marco;Brisigotti, Valerio;Rizzetto, Giulio;Bobyr, Ivan;Cirioni, Oscar;Giacometti, Andrea;Brescini, Lucia;Mazzanti, Sara;Offidani, Annamaria;Simonetti, Oriana
2022-01-01

Abstract

Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease characterized by painful nodules, abscesses, and fistulas, localized to the areas of the folds where apocrine glands are present: the armpits, groin, inframammary region, and genital or perineal region. The management is still challenging, and it includes mainly systemic antibiotics, immunosuppressors, and biologic agents. Antibiotics are frequently used in the management of HS for their anti-inflammatory, immunomodulatory, and antimicrobial properties, but no data have been reported regarding the use of dalbavancin in HS. The aim of our practice was to evaluate efficacy, flare, and disease-free survival after dalbavancin therapy in a selected population with HS. We report the experience of the Ancona Dermatology Clinic in treating HS flare-ups with dalbavancin and its rationale for use. Our observation shows that the use of dalbavancin is an effective and well-tolerated treatment for the management of Hurley stage II-III HS; currently, dalbavancin should be considered as a supportive therapy for selected patients.
2022
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11566/315732
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? 2
  • Scopus 7
  • ???jsp.display-item.citation.isi??? 7
social impact