Alarmins are endogenous, constitutively expressed, chemotacting and immune activating proteins or peptides released because of non-programmed cell death (i.e. infections, trauma, etc).They are considered endogenous damage-associated molecular patterns (DAMPs), able to induce a sterile inflammation. In the last years, several studies highlighted a possible role of different alarmins in the patho-genesis of various autoimmune and immune-mediated diseases.We reviewed the relevant literature about this topic, for about 160 articles.Particularly, we focused on systemic autoimmune diseases (systemic lupus erythematosus, rheumatoid arthritis, idiopathic inflammatory myopathies, ANCA-associated vasculitides, Behcet's disease) and cutaneous organ-specific autoimmune diseases (vitiligo, psoriasis, alopecia, pemphigo).Finally, we discussed about future perspectives and potential therapeutic implications of alarmins in auto -immune diseases. In fact, identification of receptors and downstream signal transducers of alarmins may lead to the identification of antagonistic inhibitors and agonists, with the capacity to modulate alarmins-related path-ways and potential therapeutic applicability.

Alarmins in autoimmune diseases / Danieli, Maria Giovanna; Antonelli, Eleonora; Piga, Mario Andrea; Claudi, Ilaria; Palmeri, Davide; Tonacci, Alessandro; Allegra, Alessandro; Gangemi, Sebastiano. - In: AUTOIMMUNITY REVIEWS. - ISSN 1873-0183. - STAMPA. - 21:9(2022), p. 103142. [10.1016/j.autrev.2022.103142]

Alarmins in autoimmune diseases

Danieli, Maria Giovanna
Writing – Review & Editing
;
Antonelli, Eleonora
Writing – Original Draft Preparation
;
Piga, Mario Andrea
Resources
;
Claudi, Ilaria
Resources
;
Palmeri, Davide
Resources
;
2022-01-01

Abstract

Alarmins are endogenous, constitutively expressed, chemotacting and immune activating proteins or peptides released because of non-programmed cell death (i.e. infections, trauma, etc).They are considered endogenous damage-associated molecular patterns (DAMPs), able to induce a sterile inflammation. In the last years, several studies highlighted a possible role of different alarmins in the patho-genesis of various autoimmune and immune-mediated diseases.We reviewed the relevant literature about this topic, for about 160 articles.Particularly, we focused on systemic autoimmune diseases (systemic lupus erythematosus, rheumatoid arthritis, idiopathic inflammatory myopathies, ANCA-associated vasculitides, Behcet's disease) and cutaneous organ-specific autoimmune diseases (vitiligo, psoriasis, alopecia, pemphigo).Finally, we discussed about future perspectives and potential therapeutic implications of alarmins in auto -immune diseases. In fact, identification of receptors and downstream signal transducers of alarmins may lead to the identification of antagonistic inhibitors and agonists, with the capacity to modulate alarmins-related path-ways and potential therapeutic applicability.
2022
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11566/314673
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? 6
  • Scopus 12
  • ???jsp.display-item.citation.isi??? 13
social impact