Grade of satisfaction and tolerability of a medical device based on p. Acnes in adults waiting for destructive treatments for genital warts

Vulvar and vaginal warts (genital warts – GW), also known as condylomata acuminata, are one of the clinical manifes-tations of human papillomavirus (HPV) infection. Oxidative stress may have an important role in the pathogenesis of GW. A preparate of bacterial lysate based on Propionibacterium acnes (P. acnes) showed a potent antioxidant activity in vitro, sug-gesting a potential role in the treatment of GW. The aim of the present study was to evaluate the grade of satisfaction of patients who were waiting for destructive treatment, prospective enrolled and treated for 60 days with a P. acnes lysate. The effect on the number, location of the lesions and the quadrants involved was also evaluated waiting destructive approach. Anamnestic data were collected and a vulvoscopy was per-formed with an accurate description of the lesions at the first visit and after 30-60-90 and 180 days of treatment. During the study period, 69 women, fulfilling the study inclusion/ exclusion criteria, constituted the study cohort. P. acnes preparation showed a high tolerability and a high grade of satisfac-tion. Moreover, all patients included decided to wait at least 60 days before being subjected to any destructive treatment, which was then necessary only in 31.8% of cases. The results obtained with this preliminary study enable to indicate this therapy as possible innovative option in the treatment of GW. A prospective blinded RCT will be necessary to evaluate the P. Acnes preparation efficacy in the treatment of condylomatosis.