The unexpected higher level of IFN gamma in a subset of patients with acute myeloid leukemia (AML; IFN gamma(high)) upregulates immunosuppressive genes in mesenchymal stem cells (MSC) and expands regulatory T cells through IDO1 overexpression. IDO1 and IFNG gene expression was positively correlated and required both leukemia cells and MSCs, as IFN gamma(high) cells were not able to induce Tregs alone.
Hostile Takeover: Tregs Expand in IFNγ-Rich AML Microenvironment / Brent Ferrell, P.; Kordasti, Shahram Yaser. - In: CLINICAL CANCER RESEARCH. - ISSN 1557-3265. - 28:14(2022), pp. 2986-2988. [10.1158/1078-0432.CCR-22-1030]
Hostile Takeover: Tregs Expand in IFNγ-Rich AML Microenvironment
Shahram Kordasti
Writing – Original Draft Preparation
2022-01-01
Abstract
The unexpected higher level of IFN gamma in a subset of patients with acute myeloid leukemia (AML; IFN gamma(high)) upregulates immunosuppressive genes in mesenchymal stem cells (MSC) and expands regulatory T cells through IDO1 overexpression. IDO1 and IFNG gene expression was positively correlated and required both leukemia cells and MSCs, as IFN gamma(high) cells were not able to induce Tregs alone.File in questo prodotto:
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