The triglyceride-glucose index (TyG) has been proposed as a surrogate marker of insulin resistance, which is a typical trait of pregnancy. However, very few studies analyzed TyG performance as marker of insulin resistance in pregnancy, and they were limited to insulin resistance assessment at fasting rather than in dynamic conditions, i.e., during an oral glucose tolerance test (OGTT), which allows more reliable assessment of the actual insulin sensitivity impairment. Thus, first aim of the study was exploring in pregnancy the relationships between TyG and OGTT-derived insulin sensitivity. In addition, we developed a new version of TyG, for improved performance as marker of insulin resistance in pregnancy.
TyGIS: improved triglyceride-glucose index for the assessment of insulin sensitivity during pregnancy / Salvatori, Benedetta; Linder, Tina; Eppel, Daniel; Morettini, Micaela; Burattini, Laura; Göbl, Christian; Tura, Andrea. - In: CARDIOVASCULAR DIABETOLOGY. - ISSN 1475-2840. - 21:1(2022). [10.1186/s12933-022-01649-8]
TyGIS: improved triglyceride-glucose index for the assessment of insulin sensitivity during pregnancy
Morettini, Micaela;Burattini, Laura;
2022-01-01
Abstract
The triglyceride-glucose index (TyG) has been proposed as a surrogate marker of insulin resistance, which is a typical trait of pregnancy. However, very few studies analyzed TyG performance as marker of insulin resistance in pregnancy, and they were limited to insulin resistance assessment at fasting rather than in dynamic conditions, i.e., during an oral glucose tolerance test (OGTT), which allows more reliable assessment of the actual insulin sensitivity impairment. Thus, first aim of the study was exploring in pregnancy the relationships between TyG and OGTT-derived insulin sensitivity. In addition, we developed a new version of TyG, for improved performance as marker of insulin resistance in pregnancy.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
