Major depressive disorder is a chronic and invalidating psychiatric illness and is associated with a greater risk of suicidal behaviors. In recent decades many data have supported a biological link between depressive states and inflammation. Pro-inflammatory cytokines have been found to rise, first of all TNF-α and IL-6. Suicidal behaviors have been consistently associated with increased levels of IL-6 and decreased levels of IL-2. The aim of this review is to investigate the relationship between inflammatory markers in depressed patients with or without suicidal attempts compared to healthy controls.
Inflammatory markers and suicidal attempts in depressed patients: A review / Marini, Stefano; Vellante, F.; Matarazzo, I.; De Berardis, D.; Serroni, N.; Gianfelice, D.; Olivieri, L.; Di Renzo, F.; Di Marco, A; Fornaro, M.; Orsolini, L.; Valchera, A.; Iasevoli, F.; Mazza, M.; Perna, G.; Martinotti, G.; Di Giannantonio, M.. - In: INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY. - ISSN 0394-6320. - 29:4(2016), pp. 583-594. [10.1177/0394632015623793]