Understanding the recognition process between bioactive natural products and their specific cellular receptors is of key importance in the drug discovery process. In this outline, some potential targets of Magnolol, a natural bioactive compound, have been identified by proteomic approaches. Among them, Importin-β1 has been considered as the most relevant one. A direct binding between Magnolol and this nuclear chaperone has been confirmed by DARTS and molecular docking, while its influence on Importin-β1 translocation has been evaluated by in vitro assays.
Chemical proteomics-guided identification of a novel biological target of the bioactive neolignan Magnolol / Cassiano, C.; Esposito, R.; Tosco, A.; Casapullo, A.; Mozzicafreddo, M.; Tringali, C.; Riccio, R.; Monti, M. C.. - In: FRONTIERS IN CHEMISTRY. - ISSN 2296-2646. - 7:FEB(2019), p. 53. [10.3389/fchem.2019.00053]
Chemical proteomics-guided identification of a novel biological target of the bioactive neolignan Magnolol
Mozzicafreddo M.;
2019-01-01
Abstract
Understanding the recognition process between bioactive natural products and their specific cellular receptors is of key importance in the drug discovery process. In this outline, some potential targets of Magnolol, a natural bioactive compound, have been identified by proteomic approaches. Among them, Importin-β1 has been considered as the most relevant one. A direct binding between Magnolol and this nuclear chaperone has been confirmed by DARTS and molecular docking, while its influence on Importin-β1 translocation has been evaluated by in vitro assays.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
