A ruthenium(ii) p-cymene derivative of quercetin was synthesized and functionally tested for cholesterol-lowering ability via direct 3-hydroxy-3-methyl-glutaryl-CoA reductase (HMGR) inhibition. Ruthenium complexation dramatically increased the inhibition potency of the parent quercetin toward HMGR, with a consequent enhancement of the cholesterol-lowering effect in hepatic cells.
A ruthenium derivative of quercetin with enhanced cholesterol-lowering activity / Cuccioloni, M.; Bonfili, L.; Mozzicafreddo, M.; Cecarini, V.; Pettinari, R.; Condello, F.; Pettinari, C.; Marchetti, F.; Angeletti, M.; Eleuteri, A. M.. - In: RSC ADVANCES. - ISSN 2046-2069. - 6:46(2016), pp. 39636-39641. [10.1039/c6ra06403e]
A ruthenium derivative of quercetin with enhanced cholesterol-lowering activity
Mozzicafreddo M.;
2016-01-01
Abstract
A ruthenium(ii) p-cymene derivative of quercetin was synthesized and functionally tested for cholesterol-lowering ability via direct 3-hydroxy-3-methyl-glutaryl-CoA reductase (HMGR) inhibition. Ruthenium complexation dramatically increased the inhibition potency of the parent quercetin toward HMGR, with a consequent enhancement of the cholesterol-lowering effect in hepatic cells.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
