Peroxiredoxin-1, a key enzyme in the cellular detoxification pathway, has been identified through a chemoproteomic approach as the main partner of theonellasterone, a marine bioactive metabolite. A combination of chemical and biochemical assays disclosed its mechanism of action at the molecular level.

Theonellasterone, a steroidal metabolite isolated from a Theonella sponge, protects peroxiredoxin-1 from oxidative stress reactions / Margarucci, L.; Monti, M. C.; Tosco, A.; Esposito, R.; Zampella, A.; Sepe, V.; Mozzicafreddo, M.; Riccio, R.; Casapullo, A.. - In: CHEMICAL COMMUNICATIONS. - ISSN 1359-7345. - 51:9(2015), pp. 1591-1593. [10.1039/c4cc09205h]

Theonellasterone, a steroidal metabolite isolated from a Theonella sponge, protects peroxiredoxin-1 from oxidative stress reactions

Mozzicafreddo M.;
2015-01-01

Abstract

Peroxiredoxin-1, a key enzyme in the cellular detoxification pathway, has been identified through a chemoproteomic approach as the main partner of theonellasterone, a marine bioactive metabolite. A combination of chemical and biochemical assays disclosed its mechanism of action at the molecular level.
2015
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11566/299982
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