Background: Surface CD157 modulates leukocyte and ovarian cancer cell adhesion and migration through the interaction with an unknown ligand. Results: CD157 binds heparin-binding domains of numerous extracellular matrix proteins with high affinity. Conclusion: The interaction of CD157 with extracellular matrix proteins is instrumental in the regulation of cell adhesion. Significance: These findings provide valuable insights into the biological mechanism responsible for the nonenzymatic functions of CD157. © 2014 by The American Society for Biochemistry and Molecular Biology, Inc. Published in the U.S.A.
Binding of CD157 protein to fibronectin regulates cell adhesion and spreading
Mozzicafreddo M.;
2014-01-01
Abstract
Background: Surface CD157 modulates leukocyte and ovarian cancer cell adhesion and migration through the interaction with an unknown ligand. Results: CD157 binds heparin-binding domains of numerous extracellular matrix proteins with high affinity. Conclusion: The interaction of CD157 with extracellular matrix proteins is instrumental in the regulation of cell adhesion. Significance: These findings provide valuable insights into the biological mechanism responsible for the nonenzymatic functions of CD157. © 2014 by The American Society for Biochemistry and Molecular Biology, Inc. Published in the U.S.A.File in questo prodotto:
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