Background: Surface CD157 modulates leukocyte and ovarian cancer cell adhesion and migration through the interaction with an unknown ligand. Results: CD157 binds heparin-binding domains of numerous extracellular matrix proteins with high affinity. Conclusion: The interaction of CD157 with extracellular matrix proteins is instrumental in the regulation of cell adhesion. Significance: These findings provide valuable insights into the biological mechanism responsible for the nonenzymatic functions of CD157. © 2014 by The American Society for Biochemistry and Molecular Biology, Inc. Published in the U.S.A.
Binding of CD157 protein to fibronectin regulates cell adhesion and spreading / Morone, S.; Augeri, S.; Cuccioloni, M.; Mozzicafreddo, M.; Angeletti, M.; Lo Buono, N.; Giacomino, A.; Ortolan, E.; Funaro, A.. - In: THE JOURNAL OF BIOLOGICAL CHEMISTRY. - ISSN 0021-9258. - 289:22(2014), pp. 15588-15601. [10.1074/jbc.M113.535070]
Binding of CD157 protein to fibronectin regulates cell adhesion and spreading
Mozzicafreddo M.;
2014-01-01
Abstract
Background: Surface CD157 modulates leukocyte and ovarian cancer cell adhesion and migration through the interaction with an unknown ligand. Results: CD157 binds heparin-binding domains of numerous extracellular matrix proteins with high affinity. Conclusion: The interaction of CD157 with extracellular matrix proteins is instrumental in the regulation of cell adhesion. Significance: These findings provide valuable insights into the biological mechanism responsible for the nonenzymatic functions of CD157. © 2014 by The American Society for Biochemistry and Molecular Biology, Inc. Published in the U.S.A.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
