CINECA IRIS Institutional Research Information System
IRIS è la soluzione IT che facilita la raccolta e la gestione dei dati relativi alle attività e ai prodotti della ricerca. Fornisce a ricercatori, amministratori e valutatori gli strumenti per monitorare i risultati della ricerca, aumentarne la visibilità e allocare in modo efficace le risorse disponibili.
EnglishBackground: LL-37 is the only human antimicrobial peptide that belongs to the cathelici-dins. The aim of the study was to evaluate the efficacy of LL-37 in the management of MRSA-in-fected surgical wounds in mice. Methods: A wound on the back of adult male BALB/c mice was made and inoculated with Staphylococcus aureus. Two control groups were formed (uninfected and not treated, C0; infected and not treated, C1) and six contaminated groups were treated, respec-tively, with: teicoplanin, LL-37, given topically and /or systemically. Histological examination of VEGF expression and micro-vessel density, and bacterial cultures of wound tissues, were per-formed. Results: Histological examination of wounds in the group treated with topical and intra-peritoneal LL-37 showed increased re-epithelialization, formation of the granulation tissue, collagen organization, and angiogenesis. Conclusions: Based on the mode of action, LL-37 has a potential future role in the management of infected wounds.
| Titolo: | Efficacy of cathelicidin ll-37 in an mrsa wound infection mouse model | |
| Autori: | ||
| Data di pubblicazione: | 2021 | |
| Rivista: | ||
| Abstract: | Background: LL-37 is the only human antimicrobial peptide that belongs to the cathelici-dins. The aim of the study was to evaluate the efficacy of LL-37 in the management of MRSA-in-fected surgical wounds in mice. Methods: A wound on the back of adult male BALB/c mice was made and inoculated with Staphylococcus aureus. Two control groups were formed (uninfected and not treated, C0; infected and not treated, C1) and six contaminated groups were treated, respec-tively, with: teicoplanin, LL-37, given topically and /or systemically. Histological examination of VEGF expression and micro-vessel density, and bacterial cultures of wound tissues, were per-formed. Results: Histological examination of wounds in the group treated with topical and intra-peritoneal LL-37 showed increased re-epithelialization, formation of the granulation tissue, collagen organization, and angiogenesis. Conclusions: Based on the mode of action, LL-37 has a potential future role in the management of infected wounds. | |
| Handle: | http://hdl.handle.net/11566/297885 | |
| Appare nelle tipologie: | 1.1 Articolo in rivista |
File in questo prodotto:
http://hdl.handle.net/11566/297885
Copyright © 2022