The in vitro anti-cryptosporidial activity of buforin II alone and in combination with azithromycin and minocycline was investigated. Buforin II showed moderate activity, which increased with increasing concentration to 55.7% suppression of growth at 20 microM. Moreover, its activity was enhanced when it was combined with either azithromycin or minocycline with >90% parasite reduction at the highest concentration tested. Buforin II may be active in inhibiting Cryptosporidium parvum growth in vitro upon combination with either azithromycin or minocycline.
Activity of buforin II alone and in combination with azithromycin and minocycline against Cryptosporidium parvum in cell culture / Giacometti, Andrea; Cirioni, Oscar; Del Prete, M. S.; Barchiesi, Francesco; Fineo, A.; Scalise, G.. - In: JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY. - ISSN 0305-7453. - STAMPA. - 47:1(2001), pp. 97-99.
Activity of buforin II alone and in combination with azithromycin and minocycline against Cryptosporidium parvum in cell culture.
GIACOMETTI, Andrea;CIRIONI, OSCAR;BARCHIESI, FRANCESCO;
2001-01-01
Abstract
The in vitro anti-cryptosporidial activity of buforin II alone and in combination with azithromycin and minocycline was investigated. Buforin II showed moderate activity, which increased with increasing concentration to 55.7% suppression of growth at 20 microM. Moreover, its activity was enhanced when it was combined with either azithromycin or minocycline with >90% parasite reduction at the highest concentration tested. Buforin II may be active in inhibiting Cryptosporidium parvum growth in vitro upon combination with either azithromycin or minocycline.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
