The present review focuses on preclinical and clinical studies conducted in the last decade that contribute to increasing knowledge on Coenzyme Q10’s role in health and disease. Classical antioxidant and bioenergetic functions of the coenzyme have been taken into consideration, as wellas novel mechanisms of action involving the redox-regulated activation of molecular pathways associated with anti-inflammatory activities. Cardiovascular research and fertility remain major fields of application of Coenzyme Q10, although novel applications, in particular in relation to topical application, are gaining considerable interest. In this respect, bioavailability represents a major challenge and the innovation in formulation aspects is gaining critical importance.

Role of Coenzyme Q 10 in Health and Disease: An Update on the Last 10 Years (2010-2020) / Cirilli, Ilenia; Damiani, Elisabetta; Vusi Dludla, Phiwayinkosi; Hargreaves, Iain; Marcheggiani, Fabio; Millichap, LAUREN ELIZABETH; Orlando, Patrick; Silvestri, Sonia; Tiano, Luca. - In: ANTIOXIDANTS. - ISSN 2076-3921. - ELETTRONICO. - 10:8(2021), pp. 1325-1348. [10.3390/antiox10081325]

Role of Coenzyme Q 10 in Health and Disease: An Update on the Last 10 Years (2010-2020)

Ilenia Cirilli
Primo
;
Elisabetta Damiani
Secondo
;
Fabio Marcheggiani;Lauren Elizabeth Millichap;Patrick Orlando;Sonia Silvestri
Penultimo
;
Luca Tiano
Ultimo
2021-01-01

Abstract

The present review focuses on preclinical and clinical studies conducted in the last decade that contribute to increasing knowledge on Coenzyme Q10’s role in health and disease. Classical antioxidant and bioenergetic functions of the coenzyme have been taken into consideration, as wellas novel mechanisms of action involving the redox-regulated activation of molecular pathways associated with anti-inflammatory activities. Cardiovascular research and fertility remain major fields of application of Coenzyme Q10, although novel applications, in particular in relation to topical application, are gaining considerable interest. In this respect, bioavailability represents a major challenge and the innovation in formulation aspects is gaining critical importance.
2021
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11566/292411
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