A new surgical procedure for the treatment of primary bladder neck obstruction with maintenance of anterograde ejaculation is proposed. In place of monolateral or bilateral bladder neck incision, associated with a loss of ejaculation rate of up to 30%, the new surgical procedure consists of laser drilling the bladder neck with a number of holes and without muscle fiber disrup- tion. The effect of this novel procedure has been studied numerically, with a simplified two-dimen- sional numerical model of the internal urethral sphincter, varying the position and the number of holes in the fibrotic region of the urethral tissue. Results show an improvement of the urethral sphincter opening by increasing the number of holes, ranging from about 6% to 16% of recovery. Moreover, a non-aligned position of holes positively influences the opening recovery. The concen- trations of maximum principal strain and stress have been registered in the proximity of the inter- face between the physiologic and diseased sphincter, and in those regions where the radial thick- ness is significantly thinner. The effects on the first five patients have been included in the study, showing improvement in micturition, lower urinary tract symptoms, sustained ejaculatory func- tion, and quality of life.

A Preliminary Validation of a New Surgical Procedure for the Treatment of Primary Bladder Neck Obstruction Using a Computational Modeling Approach

Serpilli, Michele;Zitti, Gianluca;Maranesi, Elvira;Morettini, Micaela;Lenci, Stefano;Burattini, Laura
2021

Abstract

A new surgical procedure for the treatment of primary bladder neck obstruction with maintenance of anterograde ejaculation is proposed. In place of monolateral or bilateral bladder neck incision, associated with a loss of ejaculation rate of up to 30%, the new surgical procedure consists of laser drilling the bladder neck with a number of holes and without muscle fiber disrup- tion. The effect of this novel procedure has been studied numerically, with a simplified two-dimen- sional numerical model of the internal urethral sphincter, varying the position and the number of holes in the fibrotic region of the urethral tissue. Results show an improvement of the urethral sphincter opening by increasing the number of holes, ranging from about 6% to 16% of recovery. Moreover, a non-aligned position of holes positively influences the opening recovery. The concen- trations of maximum principal strain and stress have been registered in the proximity of the inter- face between the physiologic and diseased sphincter, and in those regions where the radial thick- ness is significantly thinner. The effects on the first five patients have been included in the study, showing improvement in micturition, lower urinary tract symptoms, sustained ejaculatory func- tion, and quality of life.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11566/290912
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