Differential responsiveness to interleukin (IL)-2 between effector CD4¬+ T cells (Teff) and regulatory T cells (Treg) is a fundamental mechanism of immunoregulation. The single nucleotide polymorphism rs61839660, located within IL2RA (CD25), has been associated with the development of Crohn's disease. We sought to identify the T cell immune phenotype of IBD patients who carry this SNP.
A Crohn's disease-associated IL2RA enhancer variant determines the balance of T cell immunity by regulating responsiveness to IL-2 signaling / Goldberg, Rimma; Clough, Jennie N; Roberts, Luke B; Sanchez, Jenifer; Kordasti, Shahram; Petrov, Nedyalko; Hertweck, Arnulf; Lorenc, Anna; Jackson, Ian; Tasker, Scott; Appios, Anna; Omer, Omer; Parkes, Miles; Prescott, Natalie; Jenner, Richard G; Irving, Peter M; Lord, Graham M. - In: JOURNAL OF CROHN'S AND COLITIS. - ISSN 1873-9946. - STAMPA. - (2021). [10.1093/ecco-jcc/jjab103]