Differential responsiveness to interleukin (IL)-2 between effector CD4¬+ T cells (Teff) and regulatory T cells (Treg) is a fundamental mechanism of immunoregulation. The single nucleotide polymorphism rs61839660, located within IL2RA (CD25), has been associated with the development of Crohn's disease. We sought to identify the T cell immune phenotype of IBD patients who carry this SNP.
A Crohn's disease-associated IL2RA enhancer variant determines the balance of T cell immunity by regulating responsiveness to IL-2 signaling / Goldberg, R., Clough, J.N., Roberts, L.B., Sanchez, J., Kordasti, S., Petrov, N., Hertweck, A., Lorenc, A., Jackson, I., Tasker, S., Appios, A., Omer, O., Parkes, M., Prescott, N., Jenner, R.G., Irving, P.M., Lord, G.M.. - In: JOURNAL OF CROHN'S AND COLITIS. - ISSN 1873-9946. - STAMPA. - (2021). [10.1093/ecco-jcc/jjab103]
A Crohn's disease-associated IL2RA enhancer variant determines the balance of T cell immunity by regulating responsiveness to IL-2 signaling
Kordasti, ShahramWriting – Original Draft Preparation
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2021-01-01
Abstract
Differential responsiveness to interleukin (IL)-2 between effector CD4¬+ T cells (Teff) and regulatory T cells (Treg) is a fundamental mechanism of immunoregulation. The single nucleotide polymorphism rs61839660, located within IL2RA (CD25), has been associated with the development of Crohn's disease. We sought to identify the T cell immune phenotype of IBD patients who carry this SNP.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
