Stage I seminoma is the most frequent tumour in young men. It has a very good prognosis thanks to the use of a multidisciplinary therapeutic approach including surgery, radiotherapy and systemic chemotherapy. Late (after 2 years) and very late (after 5 years) relapses are uncommon, but not impossible, even if standardized follow-up for testicular tumours lasts up to 5 years after the diagnosis. We report a case of a 67-year-old Caucasian man with metachronous bilateral testicular seminoma who developed a retroperitoneal relapse of testicular seminoma 23 years after the first orchiectomy. Based on histological confirmation of testicular relapse, the patient underwent four cycles of systemic chemotherapy with bleomycin, etoposide and cisplatin (PEB), with no adverse reactions. He subsequently achieved complete radiological response at restaging computed tomography imaging, confirmed by the absence of glucose metabolism on positron emission tomography. In conclusion, this case report suggests the importance of longer standardized follow-up for patients treated for testicular tumours in order to detect earlier recurrence, which can be successfully treated.
Seminoma Retroperitoneal Relapse 23 Years After Surgery / Crocetti, Sonia; Tassone, Laura; Torniai, Mariangela; Pierantoni, Chiara; Burattini, Luciano; Mandolesi, Alessandra; Di Benedetto, Maika; Mantello, Giovanna; Scarpelli, Marina; Berardi, Rossana. - In: ONCOLOGY AND THERAPY. - ISSN 2366-1070. - (2021). [10.1007/s40487-021-00141-9]