Objectives: To explore the impact of sex and age on relationship between prodromal constipation and disease phenotype in Parkinson’s disease at early stages. Methods: A total of 385 Parkinson’s disease patients from the PRIAMO study were classified according to the presence of prodromal constipation and followed for 24 months. Multivariable mixed-effect models were applied. All analyses were performed separately for sex (64.1% men) and median age (different by sex: 67 years-old in men and 68 years-old in women). Results: As for sex, prodromal constipation was associated with greater odds of attention/memory complaints and apathy symptoms in women only. As for age, prodromal constipation was associated with lower cognitive and higher apathy scores in older patients only. Conclusions: Prodromal constipation anticipates lower cognitive performances and more severe apathy since the earliest stages in women and older patients. Sex- and age-related heterogeneity of prodromal markers of Parkinson’s disease may impact disease phenotype.
The PRIAMO study: age- and sex-related relationship between prodromal constipation and disease phenotype in early Parkinson’s disease / Picillo, M.; Palladino, R.; Erro, R.; Alfano, R.; Colosimo, C.; Marconi, R.; Antonini, A.; Barone, P.; Morgante, L.; Benincasa, D.; Quatrale, R.; Biguzzi, S.; Braga, M.; Ceravolo, G.; Capecci, M.; Meco, G.; Caravona, N.; Scala, R.; De Falco, F. A.; Pezzoli, G.; De Gaspari, D.; Bottacchi, E.; Di Giovanni, M.; Cannas, A.; Floris, G.; Gallerini, S.; Grasso, L.; Gaglio, R. M.; Gurgone, G.; Volpe, G.; Zappulla, S.; Ceravolo, R.; Kiferle, L.; Ramat, S.; Meoni, S.; Pisani, A.; Moschella, V.; Morgante, F.; Savica, R.; Pepe, F.; Ciccarelli, G.; Petretta, V.; Giglia, R. M.; Randisi, M. G.; Iemolo, F.; Avarello, T. P.; Romeno, M.; Santangelo, G.; Stocchi, F.; Sciortino, G.; Sorbello, V.; Nicoletti, A.; Tiple, D.; Fabbrini, G.; Bentivoglio, A.; Pontieri, F. E.; Guidubaldi, A.; Muoio, R.; Toni, V.; Del Dotto, P.; Logi, C.; Ciacci, G.; Ulivelli, M.; Perini, M.; Lanfranchi, S.; Griffini, S.; Troianiello, B.; Baratti, M.; Amidei, S.; Consoli, D.; Iellamo, M.; Cuomo, T.; Scaglioni, A.; Medici, D.; Manfredi, M.; Abbruzzese, G.; Di Brigida, G.; Cocco, G. A.; Agnetti, V.; Cossu, G.; Deriu, M.; Abrignani, M.; Modica, C.; Albani, G.; Milan, E.; Martinelli, P.; Scaglione, C.; Mucchiut, M.; Zanini, S.; Pennisi, F.; Soliveri, P.; Albanese, A.; Massimo, P.; Bartolomei, L.; Capus, L.; Ferigo, L.; Marano, R.; Nastasi, V.; Luciano, R.; Maiello, L.; Simone, P.; Fogli, D.; Lopiano, L.; Pesare, M.; Nordera, G.; Pilleri, E.; Scaravilli, T.; Giaccaglini, E.; Alesi, C.; Petrone, A.; Trianni, G.. - In: JOURNAL OF NEUROLOGY. - ISSN 0340-5354. - ELETTRONICO. - 268:2(2020), pp. 448-454. [10.1007/s00415-020-10156-3]
The PRIAMO study: age- and sex-related relationship between prodromal constipation and disease phenotype in early Parkinson’s disease
Ceravolo G.;Capecci M.;
2020-01-01
Abstract
Objectives: To explore the impact of sex and age on relationship between prodromal constipation and disease phenotype in Parkinson’s disease at early stages. Methods: A total of 385 Parkinson’s disease patients from the PRIAMO study were classified according to the presence of prodromal constipation and followed for 24 months. Multivariable mixed-effect models were applied. All analyses were performed separately for sex (64.1% men) and median age (different by sex: 67 years-old in men and 68 years-old in women). Results: As for sex, prodromal constipation was associated with greater odds of attention/memory complaints and apathy symptoms in women only. As for age, prodromal constipation was associated with lower cognitive and higher apathy scores in older patients only. Conclusions: Prodromal constipation anticipates lower cognitive performances and more severe apathy since the earliest stages in women and older patients. Sex- and age-related heterogeneity of prodromal markers of Parkinson’s disease may impact disease phenotype.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
