Natural products and their structural analogues have historically made a major contribution to pharmacotherapy, especially for cancer and infectious diseases. Nevertheless, natural products also present challenges for drug discovery, such as technical barriers to screening, isolation, characterization and optimization, which contributed to a decline in their pursuit by the pharmaceutical industry from the 1990s onwards. In recent years, several technological and scientific developments — including improved analytical tools, genome mining and engineering strategies, and microbial culturing advances — are addressing such challenges and opening up new opportunities. Consequently, interest in natural products as drug leads is being revitalized, particularly for tackling antimicrobial resistance. Here, we summarize recent technological developments that are enabling natural product-based drug discovery, highlight selected applications and discuss key opportunities.
Natural products in drug discovery: advances and opportunities / Atanasov, A. G.; Zotchev, S. B.; Dirsch, V. M.; Supuran, C. T.; the International Natural Product Sciences, Taskforce; Battino, M.; Giampieri, F.. - In: NATURE REVIEWS DRUG DISCOVERY. - ISSN 1474-1776. - ELETTRONICO. - 20:3(2021), pp. 200-216. [10.1038/s41573-020-00114-z]
Natural products in drug discovery: advances and opportunities
Battino M.Membro del Collaboration Group
;Giampieri F.Membro del Collaboration Group
2021-01-01
Abstract
Natural products and their structural analogues have historically made a major contribution to pharmacotherapy, especially for cancer and infectious diseases. Nevertheless, natural products also present challenges for drug discovery, such as technical barriers to screening, isolation, characterization and optimization, which contributed to a decline in their pursuit by the pharmaceutical industry from the 1990s onwards. In recent years, several technological and scientific developments — including improved analytical tools, genome mining and engineering strategies, and microbial culturing advances — are addressing such challenges and opening up new opportunities. Consequently, interest in natural products as drug leads is being revitalized, particularly for tackling antimicrobial resistance. Here, we summarize recent technological developments that are enabling natural product-based drug discovery, highlight selected applications and discuss key opportunities.| File | Dimensione | Formato | |
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Descrizione: This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use https:// www.springernature.com/gp/open-research/policies/accepted-manuscript-terms, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: https://doi.org/10.1038/ s41573-020-00114-z
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