Most intraductal carcinoma of the prostate (IDC-P) lesions are likely derived from retrograde spreading of cancer cells into adjacent benign ducts. Tumor cells in IDC-P frequently display a high degree of genomic instability. Germline mutations in DNA repair genes are implicated in IDC-P tumorigenesis.
Intraductal Carcinoma of the Prostate: Pathogenesis and Molecular Perspectives / Zong, Y.; Montironi, R.; Massari, F.; Jiang, Z.; Lopez-Beltran, A.; Wheeler, T. M.; Scarpelli, M.; Santoni, M.; Cimadamore, A.; Cheng, L.. - In: EUROPEAN UROLOGY FOCUS. - ISSN 2405-4569. - (2020). [10.1016/j.euf.2020.10.007]
Intraductal Carcinoma of the Prostate: Pathogenesis and Molecular Perspectives
Montironi R.;Scarpelli M.;Santoni M.;Cimadamore A.;
2020-01-01
Abstract
Most intraductal carcinoma of the prostate (IDC-P) lesions are likely derived from retrograde spreading of cancer cells into adjacent benign ducts. Tumor cells in IDC-P frequently display a high degree of genomic instability. Germline mutations in DNA repair genes are implicated in IDC-P tumorigenesis.File in questo prodotto:
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