The development of targeted therapies increases treatment options for metastatic castration resistant prostate cancer (mCRPC) patients. There is a need for strong predictive and prognostic signatures to guide physicians in treating mCRPC patients. In this review we unravel the possible actionability in the AR pathway, PI3K AKT signaling, and DNA repair pathways. Additionally, we make recommendations on biomarker trial design, and the clinical use of this new type of data.
Clinical Actionability of the Genomic Landscape of Metastatic Castration Resistant Prostate Cancer / Devlies, Wout; Eckstein, Markus; Cimadamore, Alessia; Devos, Gaëtan; Moris, Lisa; Van Den Broeck, Thomas; Montironi, Rodolfo; Joniau, Steven; Claessens, Frank; Gevaert, Thomas. - In: CELLS. - ISSN 2073-4409. - 9:11(2020), p. 2494. [10.3390/cells9112494]
Clinical Actionability of the Genomic Landscape of Metastatic Castration Resistant Prostate Cancer
Alessia Cimadamore;Rodolfo Montironi;
2020-01-01
Abstract
The development of targeted therapies increases treatment options for metastatic castration resistant prostate cancer (mCRPC) patients. There is a need for strong predictive and prognostic signatures to guide physicians in treating mCRPC patients. In this review we unravel the possible actionability in the AR pathway, PI3K AKT signaling, and DNA repair pathways. Additionally, we make recommendations on biomarker trial design, and the clinical use of this new type of data.| File | Dimensione | Formato | |
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