Dicarbonyl stress is a dysfunctional state consisting in the abnormal accumulation of reactive α-oxaldehydes leading to increased protein modification. In cells, post-translational changes can also occur through S-glutathionylation, a highly conserved oxidative post-translational modification consisting of the formation of a mixed disulfide between glutathione and a protein cysteine residue. This review recapitulates the main findings supporting a role for dicarbonyl stress and S-glutathionylation in the pathogenesis of cerebrovascular diseases, with specific emphasis on cerebral cavernous malformations (CCM), a vascular disease of proven genetic origin that may give rise to various clinical signs and symptoms at any age, including recurrent headaches, seizures, focal neurological deficits, and intracerebral hemorrhage. A possible interplay between dicarbonyl stress and S-glutathionylation in CCM is also discussed.
Dicarbonyl stress and s-glutathionylation in cerebrovascular diseases: A focus on cerebral cavernous malformations / Antognelli, C.; Perrelli, A.; Armeni, T.; Talesa, V. N.; Retta, S. F.. - In: ANTIOXIDANTS. - ISSN 2076-3921. - ELETTRONICO. - 9:2(2020). [10.3390/antiox9020124]