Background: Even if there is sparse evidence of efficacy of stem cell administration for amyotrophic lateral sclerosis (ALS) in preclinical studies, the clinical use of cell-based therapy is yet to be defined. Objective: to assess the efficacy, feasibility and safety of cell-based therapy in people with ALS/MND., compared with placebo or no treatment. Methods: A Cochrane Review on the topic was summarized with comments. Results: Two RCTs met the selection criteria, but only one provided data useful for the analysis. It compared autologous bone marrow-mesenchymal stem cells, combined with riluzole, to riluzole only, in 64 people with ALS. ALSFRS-R score slightly improved 6 months after the intervention, though the change was not clinically meaningful. Respiratory function, overall survival and the risk of total adverse events or serious adverse events were not different in the two groups. Conclusions: The available evidence does not support the use of bone marrow-mesenchymal stem cells to treat people with ALS/MND.

Is cell-based therapy more efficacious for people with amyotrophic lateral sclerosis/motor neuron disease than placebo or no treatment? - A Cochrane review summary with commentary / Ceravolo, Maria Gabriella. - In: NEUROREHABILITATION. - ISSN 1053-8135. - ELETTRONICO. - (2020), pp. 1-3. [10.3233/NRE-209004]

Is cell-based therapy more efficacious for people with amyotrophic lateral sclerosis/motor neuron disease than placebo or no treatment? - A Cochrane review summary with commentary

Ceravolo, Maria Gabriella
2020-01-01

Abstract

Background: Even if there is sparse evidence of efficacy of stem cell administration for amyotrophic lateral sclerosis (ALS) in preclinical studies, the clinical use of cell-based therapy is yet to be defined. Objective: to assess the efficacy, feasibility and safety of cell-based therapy in people with ALS/MND., compared with placebo or no treatment. Methods: A Cochrane Review on the topic was summarized with comments. Results: Two RCTs met the selection criteria, but only one provided data useful for the analysis. It compared autologous bone marrow-mesenchymal stem cells, combined with riluzole, to riluzole only, in 64 people with ALS. ALSFRS-R score slightly improved 6 months after the intervention, though the change was not clinically meaningful. Respiratory function, overall survival and the risk of total adverse events or serious adverse events were not different in the two groups. Conclusions: The available evidence does not support the use of bone marrow-mesenchymal stem cells to treat people with ALS/MND.
2020
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11566/282513
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 1
  • ???jsp.display-item.citation.isi??? 1
social impact