Prolonged adrenal stimulation by corticotropin, as in long-standing Cushing disease (CD), leads to diffuse to nodular hyperplasia. Adrenal functional autonomy has been described in a subset of patients with CD, leading to the hypothesis of transition from ACTH-dependent to ACTH-independent hypercortisolism.

Somatic PRKACA Mutations: Association With Transition From Pituitary-Dependent to Adrenal-Dependent Cushing Syndrome / Di Dalmazi, Guido; Timmers, Henri J L M; Arnaldi, Giorgio; Küsters, Benno; Scarpelli, Marina; Bathon, Kerstin; Calebiro, Davide; Beuschlein, Felix; Hermus, Ad; Reincke, Martin. - In: THE JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM. - ISSN 1945-7197. - STAMPA. - 104:11(2019), p. 5651-5657. [10.1210/jc.2018-02209]

Somatic PRKACA Mutations: Association With Transition From Pituitary-Dependent to Adrenal-Dependent Cushing Syndrome

Arnaldi, Giorgio;Scarpelli, Marina;
2019-01-01

Abstract

Prolonged adrenal stimulation by corticotropin, as in long-standing Cushing disease (CD), leads to diffuse to nodular hyperplasia. Adrenal functional autonomy has been described in a subset of patients with CD, leading to the hypothesis of transition from ACTH-dependent to ACTH-independent hypercortisolism.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11566/278587
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