A prompt diagnosis of Cushing's Syndrome (CS) in high-risk populations is mandatory: 1-mg dexamethasone suppression test (1-mg DST), late night salivary cortisol (LNSC), and urinary-free cortisol (UFC) are recommended, despite thresholds calculated in retrospective studies. Our aim was to study the diagnostic accuracy of LNSC measured with chemiluminescence assay in a prospective study, confirming discrepancies with mass spectrometry (MS).

The diagnostic accuracy of increased late night salivary cortisol for Cushing's syndrome: a real-life prospective study / Ceccato, F; Marcelli, G; Martino, M; Concettoni, C; Brugia, M; Trementino, L; Michetti, G; Arnaldi, G. - In: JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION. - ISSN 1720-8386. - STAMPA. - 42:3(2019), p. 327-335. [10.1007/s40618-018-0921-1]

The diagnostic accuracy of increased late night salivary cortisol for Cushing's syndrome: a real-life prospective study

Martino, M;Concettoni, C;Brugia, M;Trementino, L;Michetti, G;Arnaldi, G
2019-01-01

Abstract

A prompt diagnosis of Cushing's Syndrome (CS) in high-risk populations is mandatory: 1-mg dexamethasone suppression test (1-mg DST), late night salivary cortisol (LNSC), and urinary-free cortisol (UFC) are recommended, despite thresholds calculated in retrospective studies. Our aim was to study the diagnostic accuracy of LNSC measured with chemiluminescence assay in a prospective study, confirming discrepancies with mass spectrometry (MS).
2019
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11566/278567
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