A prompt diagnosis of Cushing's Syndrome (CS) in high-risk populations is mandatory: 1-mg dexamethasone suppression test (1-mg DST), late night salivary cortisol (LNSC), and urinary-free cortisol (UFC) are recommended, despite thresholds calculated in retrospective studies. Our aim was to study the diagnostic accuracy of LNSC measured with chemiluminescence assay in a prospective study, confirming discrepancies with mass spectrometry (MS).
The diagnostic accuracy of increased late night salivary cortisol for Cushing's syndrome: a real-life prospective study / Ceccato, F; Marcelli, G; Martino, M; Concettoni, C; Brugia, M; Trementino, L; Michetti, G; Arnaldi, G. - In: JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION. - ISSN 1720-8386. - STAMPA. - 42:3(2019), p. 327-335. [10.1007/s40618-018-0921-1]