HER2-positive early breast cancer is a heterogenous disease. We assessed the role of body mass index (BMI) and hormone receptors (HRs) in 238 women who completed adjuvant chemotherapy and 1 year of treatment with trastuzumab. Three-year recurrence risk resulted as higher for HR-negative (HR−) patients with BMI ≥25 compared with HR+ patients with BMI <25, suggesting that this particular subpopulation of patients might benefit from escalation approaches in adjuvant treatment.
Body Mass Index and Hormone Receptor Status Influence Recurrence Risk in HER2-Positive Early Breast Cancer Patients
Cantini L.;Pistelli M.;Merloni F.;Bastianelli L.;Della Mora A.;Santinelli A.;Savini A.;Maccaroni E.;Berardi R.
2020-01-01
Abstract
HER2-positive early breast cancer is a heterogenous disease. We assessed the role of body mass index (BMI) and hormone receptors (HRs) in 238 women who completed adjuvant chemotherapy and 1 year of treatment with trastuzumab. Three-year recurrence risk resulted as higher for HR-negative (HR−) patients with BMI ≥25 compared with HR+ patients with BMI <25, suggesting that this particular subpopulation of patients might benefit from escalation approaches in adjuvant treatment.File in questo prodotto:
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