Shift work is associated with alterations in the human biological clock and metabolism. Serum exosomal miR-92a concentration was inversely correlated with brown adipose tissue activity playing a pivotal role in energy balance. In this study, miR-92a was measured in serum exosomes of 30 workers engaged in shift and daytime work. No significant metabolic alterations were shown between daytime and shift workers while a difference in serum exosomal miR-92a levels was found between the two groups. The lower levels of miR-92a in shift workers were suggestive of a higher brown adipose tissue activity compared with daytime workers. However, the possibility that other physiological and pathological processes may influence miR-92a cannot be ruled out. Our results suggest further investigations on brown adipose tissue activity and on miR-92a regulatory mechanisms, such as those related to the estrogen pathway, in shift workers.
Exosomal miR-92a concentration in the serum of shift workers / Bracci, M.; Elexpuru Zabaleta, M.; Tartaglione, M. F.; Ledda, C.; Rapisarda, V.; Santarelli, L.. - In: APPLIED SCIENCES. - ISSN 2076-3417. - 10:2(2020), p. 430. [10.3390/app10020430]