In recent biomedical studies different nanocarrier systems have been proposed for 'smart' drug delivery. The engineering of these systems requires as a prerequisite a detailed knowledge of their structure and dynamics at the molecular level. Quasielastic neutron scattering is an ideal tool for dynamic studies of these complex systems since it provides information on molecular motions in a time window which is important to relate the local dynamics to the macroscopic functional properties of the drug vectors. Some selected examples referring to different nanostructures will be analysed in the following.
Dynamics of Nanostructures for Drug Delivery: the Potential of QENS / Deriu, Antonio; Bari, Maria Teresa Di; Gerelli, Yuri. - In: ZEITSCHRIFT FÜR PHYSIKALISCHE CHEMIE. - ISSN 0942-9352. - ELETTRONICO. - 224:(2010), pp. 227-242. [10.1524/zpch.2010.6101]
Dynamics of Nanostructures for Drug Delivery: the Potential of QENS
Gerelli, Yuri
2010-01-01
Abstract
In recent biomedical studies different nanocarrier systems have been proposed for 'smart' drug delivery. The engineering of these systems requires as a prerequisite a detailed knowledge of their structure and dynamics at the molecular level. Quasielastic neutron scattering is an ideal tool for dynamic studies of these complex systems since it provides information on molecular motions in a time window which is important to relate the local dynamics to the macroscopic functional properties of the drug vectors. Some selected examples referring to different nanostructures will be analysed in the following.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
