Human leukocyte antigen (HLA)-DQ2 and/or -DQ8 is an essential risk factor for celiac disease (CD). About 90-95% of patients with CD carry HLA-DQ2/-DQ8 alleles, and HLA-DQ typing is considered an additional diagnostic test. Conventional polymerase chain reaction (PCR)-based HLA-DQ typing methods are expensive, complex, and a time-consuming process. We assessed the efficacy of a novel HLA-DQ typing method, "Celiac Gene Screen," for the detection of CD-associated HLA haplotypes.
Validation of a novel single-drop rapid human leukocyte antigen-DQ2/-DQ8 typing method to identify subjects susceptible to celiac disease / Verma, Anil K; Singh, Alka; Gatti, Simona; Lionetti, Elena; Galeazzi, Tiziana; Monachesi, Chiara; Franceschini, Elisa; Ahuja, Vineet; Catassi, Carlo; Makharia, Govind K. - In: JGH OPEN. - ISSN 2397-9070. - STAMPA. - 2:6(2018), pp. 311-316-316. [10.1002/jgh3.12090]
Validation of a novel single-drop rapid human leukocyte antigen-DQ2/-DQ8 typing method to identify subjects susceptible to celiac disease
Verma, Anil K;Gatti, Simona;Lionetti, Elena;Galeazzi, Tiziana;Monachesi, Chiara;Catassi, Carlo;
2018-01-01
Abstract
Human leukocyte antigen (HLA)-DQ2 and/or -DQ8 is an essential risk factor for celiac disease (CD). About 90-95% of patients with CD carry HLA-DQ2/-DQ8 alleles, and HLA-DQ typing is considered an additional diagnostic test. Conventional polymerase chain reaction (PCR)-based HLA-DQ typing methods are expensive, complex, and a time-consuming process. We assessed the efficacy of a novel HLA-DQ typing method, "Celiac Gene Screen," for the detection of CD-associated HLA haplotypes.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
