The Model for End-Stage Liver Disease (MELD) score is widely used to prioritize patients for liver transplantation. One of the pitfalls of the MELD score is the interlaboratory variability in all three components of the score (INR, bilirubin, creatinine). The interlaboratory variability in the INR has the largest impact on the MELD score, with a mean difference of around 5 MELD points in most studies. During the 3rd conference on Coagulopathy and Liver disease, a multidisciplinary group of scientists and physicians discussed possible solutions for the INR problem in the MELD score with the intention to provide a constructive contribution to the international debate on this issue. Here we will discuss possible solutions and highlight advantages and disadvantages.
The International Normalized Ratio (INR) in the MELD score: problems and solutions / Porte, Rj; Lisman, T; Tripodi, A; Caldwell, Sh; Trotter, Jf; Coagulation in Liver Disease Study, Group; Anstee, Q; Berg, C; de Boer, M; Burroughs, A; Chowdary, P; de Groot, P; Janssen, H; Leebeek, F; Lesurtel, M; Levi, M; Levy, J; Northup, P; Sanyal, A; Senzolo, M; Stravtiz, T; Valla, D; Violi, F; Vivarelli, M; Witters, P; de Wolf, J.. - In: AMERICAN JOURNAL OF TRANSPLANTATION. - ISSN 1600-6135. - ELETTRONICO. - 10:6(2010), pp. 1349-1353. [10.1111/j.1600-6143.2010.03064.x]
The International Normalized Ratio (INR) in the MELD score: problems and solutions.
Vivarelli M;
2010-01-01
Abstract
The Model for End-Stage Liver Disease (MELD) score is widely used to prioritize patients for liver transplantation. One of the pitfalls of the MELD score is the interlaboratory variability in all three components of the score (INR, bilirubin, creatinine). The interlaboratory variability in the INR has the largest impact on the MELD score, with a mean difference of around 5 MELD points in most studies. During the 3rd conference on Coagulopathy and Liver disease, a multidisciplinary group of scientists and physicians discussed possible solutions for the INR problem in the MELD score with the intention to provide a constructive contribution to the international debate on this issue. Here we will discuss possible solutions and highlight advantages and disadvantages.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
