Between-individual variability in brain structure is determined by gene-environment interactions, possibly reflecting differential sensitivity to environmental and genetic perturbations. Magnetic resonance imaging (MRI) studies have revealed thinner cortices and smaller subcortical volumes in patients with schizophrenia. However, group-level comparisons may mask considerable within-group heterogeneity, which has largely remained unnoticed in the literature.
Brain Heterogeneity in Schizophrenia and Its Association With Polygenic Risk / Alnæs, D., Kaufmann, T., van der Meer, D., Córdova-Palomera, A., Rokicki, J., Moberget, T., Bettella, F., Agartz, I., Barch, D.M., Bertolino, A., Brandt, C.L., Cervenka, S., Djurovic, S., Doan, N.T., Eisenacher, S., Fatouros-Bergman, H., Flyckt, L., Di Giorgio, A., Haatveit, B., Jönsson, E.G., et al.. - In: JAMA PSYCHIATRY. - ISSN 2168-622X. - ELETTRONICO. - (2019). [10.1001/jamapsychiatry.2019.0257]
Brain Heterogeneity in Schizophrenia and Its Association With Polygenic Risk
Di Giorgio, AnnabellaMembro del Collaboration Group
;
2019-01-01
Abstract
Between-individual variability in brain structure is determined by gene-environment interactions, possibly reflecting differential sensitivity to environmental and genetic perturbations. Magnetic resonance imaging (MRI) studies have revealed thinner cortices and smaller subcortical volumes in patients with schizophrenia. However, group-level comparisons may mask considerable within-group heterogeneity, which has largely remained unnoticed in the literature.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
