Between-individual variability in brain structure is determined by gene-environment interactions, possibly reflecting differential sensitivity to environmental and genetic perturbations. Magnetic resonance imaging (MRI) studies have revealed thinner cortices and smaller subcortical volumes in patients with schizophrenia. However, group-level comparisons may mask considerable within-group heterogeneity, which has largely remained unnoticed in the literature.
Brain Heterogeneity in Schizophrenia and Its Association With Polygenic Risk / Alnæs, Dag; Kaufmann, Tobias; van der Meer, Dennis; Córdova-Palomera, Aldo; Rokicki, Jaroslav; Moberget, Torgeir; Bettella, Francesco; Agartz, Ingrid; Barch, Deanna M; Bertolino, Alessandro; Brandt, Christine L; Cervenka, Simon; Djurovic, Srdjan; Doan, Nhat Trung; Eisenacher, Sarah; Fatouros-Bergman, Helena; Flyckt, Lena; Di Giorgio, Annabella; Haatveit, Beathe; Jönsson, Erik G; Kirsch, Peter; Lund, Martina J; Meyer-Lindenberg, Andreas; Pergola, Giulio; Schwarz, Emanuel; Smeland, Olav B; Quarto, Tiziana; Zink, Mathias; Andreassen, Ole A; Westlye, Lars T. - In: JAMA PSYCHIATRY. - ISSN 2168-622X. - ELETTRONICO. - (2019). [10.1001/jamapsychiatry.2019.0257]
Brain Heterogeneity in Schizophrenia and Its Association With Polygenic Risk
Di Giorgio, AnnabellaMembro del Collaboration Group
;
2019-01-01
Abstract
Between-individual variability in brain structure is determined by gene-environment interactions, possibly reflecting differential sensitivity to environmental and genetic perturbations. Magnetic resonance imaging (MRI) studies have revealed thinner cortices and smaller subcortical volumes in patients with schizophrenia. However, group-level comparisons may mask considerable within-group heterogeneity, which has largely remained unnoticed in the literature.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
