Aqueous solutions of guanosine-5'-monophosphates (GMP) - known to form G-quadruplexes and liquid crystal phases - can be induced to turn into high water content gels by the addition of guanosine (Gua). By a combination of Light Scattering (LS) and AFM we show that Gua/GMP hydrogels are microscopically heterogeneous, formed by Gua-rich disordered microcoils of intertwined filaments ("knots") connected by GMP-rich long linear threads. The different thermal stability of knots and threads controls the gel transition.
Quadruplex knots as network nodes: nano-partitioning of guanosine derivates in supramolecular hydrogels / Nava, Giovanni; Carducci, Federica; Itri, Rosangela; Yoneda Juliana, Sakamoto; Bellini, Tommaso; Mariani, Paolo.. - In: SOFT MATTER. - ISSN 1744-683X. - ELETTRONICO. - 15:11(2019), pp. 2315-2318. [10.1039/C8SM02616E]
Quadruplex knots as network nodes: nano-partitioning of guanosine derivates in supramolecular hydrogels
Carducci Federica;Mariani Paolo.
2019-01-01
Abstract
Aqueous solutions of guanosine-5'-monophosphates (GMP) - known to form G-quadruplexes and liquid crystal phases - can be induced to turn into high water content gels by the addition of guanosine (Gua). By a combination of Light Scattering (LS) and AFM we show that Gua/GMP hydrogels are microscopically heterogeneous, formed by Gua-rich disordered microcoils of intertwined filaments ("knots") connected by GMP-rich long linear threads. The different thermal stability of knots and threads controls the gel transition.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
